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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VPS4B
All Species:
28.48
Human Site:
Y40
Identified Species:
48.21
UniProt:
O75351
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75351
NP_004860.2
444
49302
Y40
L
Y
Q
H
A
V
Q
Y
F
L
H
V
V
K
Y
Chimpanzee
Pan troglodytes
XP_001146376
412
45621
Y40
L
Y
Q
H
A
V
Q
Y
F
L
H
V
V
K
Y
Rhesus Macaque
Macaca mulatta
XP_001093648
516
56751
Y117
L
Y
Q
H
A
V
E
Y
F
L
H
A
I
K
Y
Dog
Lupus familis
XP_848812
444
49189
Y40
L
Y
Q
H
A
V
Q
Y
F
L
H
V
V
K
Y
Cat
Felis silvestris
Mouse
Mus musculus
P46467
444
49401
Y40
L
Y
Q
H
A
V
Q
Y
F
L
H
V
V
K
Y
Rat
Rattus norvegicus
Q5XIK7
488
55183
W52
D
P
A
T
K
A
K
W
Q
Q
V
R
Q
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510255
484
54482
Y85
L
Y
Q
H
A
V
E
Y
F
L
H
A
I
K
Y
Chicken
Gallus gallus
Q1HGK7
492
56020
T46
Y
L
Y
S
L
R
D
T
Y
L
Q
Q
K
W
Q
Frog
Xenopus laevis
Q9PUL2
486
55412
Y41
D
Q
M
N
K
Y
L
Y
S
V
K
D
T
F
L
Zebra Danio
Brachydanio rerio
Q5U3S1
488
54873
P46
H
C
Q
S
L
R
D
P
A
Q
K
V
K
W
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393250
441
49311
Y46
Y
F
L
H
S
I
K
Y
E
A
Q
G
D
R
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
O61577
516
57575
T41
Q
Q
I
Q
K
L
L
T
S
V
H
E
P
Q
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SEX2
523
57218
Q40
F
F
D
G
A
I
A
Q
I
N
K
H
L
N
T
Baker's Yeast
Sacchar. cerevisiae
P52917
437
48154
Y46
Y
L
M
L
A
L
K
Y
E
K
N
P
K
S
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.7
70.1
96.4
N.A.
95.5
35.2
N.A.
74.1
36.3
36.4
36.4
N.A.
N.A.
75.9
N.A.
34.8
Protein Similarity:
100
92.7
79
97.5
N.A.
97.3
54.9
N.A.
83.4
54.2
54.1
54.9
N.A.
N.A.
87.8
N.A.
53.1
P-Site Identity:
100
100
80
100
N.A.
100
0
N.A.
80
6.6
6.6
13.3
N.A.
N.A.
13.3
N.A.
6.6
P-Site Similarity:
100
100
93.3
100
N.A.
100
20
N.A.
93.3
13.3
20
13.3
N.A.
N.A.
46.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
35.5
61
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
54.1
74.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
58
8
8
0
8
8
0
15
0
0
8
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
15
0
8
0
0
0
15
0
0
0
0
8
8
0
0
% D
% Glu:
0
0
0
0
0
0
15
0
15
0
0
8
0
8
0
% E
% Phe:
8
15
0
0
0
0
0
0
43
0
0
0
0
8
0
% F
% Gly:
0
0
0
8
0
0
0
0
0
0
0
8
0
0
0
% G
% His:
8
0
0
50
0
0
0
0
0
0
50
8
0
0
0
% H
% Ile:
0
0
8
0
0
15
0
0
8
0
0
0
15
0
0
% I
% Lys:
0
0
0
0
22
0
22
0
0
8
22
0
22
43
8
% K
% Leu:
43
15
8
8
15
15
15
0
0
50
0
0
8
0
15
% L
% Met:
0
0
15
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
0
0
0
8
8
0
0
8
0
% N
% Pro:
0
8
0
0
0
0
0
8
0
0
0
8
8
0
0
% P
% Gln:
8
15
50
8
0
0
29
8
8
15
15
8
8
8
15
% Q
% Arg:
0
0
0
0
0
15
0
0
0
0
0
8
0
8
8
% R
% Ser:
0
0
0
15
8
0
0
0
15
0
0
0
0
8
0
% S
% Thr:
0
0
0
8
0
0
0
15
0
0
0
0
8
0
8
% T
% Val:
0
0
0
0
0
43
0
0
0
15
8
36
29
0
0
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
0
0
0
15
0
% W
% Tyr:
22
43
8
0
0
8
0
65
8
0
0
0
0
0
43
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _