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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ENTPD5
All Species:
23.94
Human Site:
S114
Identified Species:
47.88
UniProt:
O75356
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75356
NP_001240.1
428
47517
S114
L
L
E
V
A
K
D
S
I
P
R
S
H
W
K
Chimpanzee
Pan troglodytes
XP_510057
428
47543
S114
L
L
E
V
A
K
D
S
I
P
R
S
H
W
K
Rhesus Macaque
Macaca mulatta
XP_001092475
428
47501
S114
L
L
E
V
A
K
D
S
I
P
R
S
H
W
K
Dog
Lupus familis
XP_853865
428
47445
S114
L
L
E
V
A
K
D
S
I
P
Q
S
H
W
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9WUZ9
427
47083
S113
L
L
E
V
A
K
D
S
I
P
R
S
H
W
E
Rat
Rattus norvegicus
Q9ER31
455
49881
H138
L
L
N
V
A
K
Q
H
I
P
Y
D
F
W
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
O93295
493
54016
G125
T
Y
L
G
A
T
A
G
M
R
L
L
R
E
Q
Frog
Xenopus laevis
NP_001089154
468
52036
E153
L
L
N
I
A
K
K
E
I
P
Q
K
L
W
A
Zebra Danio
Brachydanio rerio
XP_684862
450
50634
T136
L
L
K
V
A
K
K
T
I
P
K
E
Q
W
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_722860
464
51101
F147
L
L
D
E
A
R
A
F
I
P
K
E
H
W
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9XU84
479
53825
E112
L
L
Q
R
A
R
K
E
V
P
H
F
M
W
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32621
518
56803
Y156
L
L
K
V
A
M
N
Y
V
P
I
K
A
R
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.6
92.7
N.A.
88
47
N.A.
N.A.
29.6
44
53.1
N.A.
35.1
N.A.
32.7
N.A.
Protein Similarity:
100
99.7
98.8
96.7
N.A.
93.6
61.5
N.A.
N.A.
43.6
58.7
70
N.A.
52.7
N.A.
49.2
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
60
N.A.
N.A.
6.6
46.6
53.3
N.A.
46.6
N.A.
33.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
60
N.A.
N.A.
20
60
73.3
N.A.
66.6
N.A.
60
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
30.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
100
0
17
0
0
0
0
0
9
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
0
0
0
42
0
0
0
0
9
0
0
0
% D
% Glu:
0
0
42
9
0
0
0
17
0
0
0
17
0
9
17
% E
% Phe:
0
0
0
0
0
0
0
9
0
0
0
9
9
0
0
% F
% Gly:
0
0
0
9
0
0
0
9
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
9
0
0
9
0
50
0
0
% H
% Ile:
0
0
0
9
0
0
0
0
75
0
9
0
0
0
9
% I
% Lys:
0
0
17
0
0
67
25
0
0
0
17
17
0
0
42
% K
% Leu:
92
92
9
0
0
0
0
0
0
0
9
9
9
0
0
% L
% Met:
0
0
0
0
0
9
0
0
9
0
0
0
9
0
0
% M
% Asn:
0
0
17
0
0
0
9
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
92
0
0
0
0
0
% P
% Gln:
0
0
9
0
0
0
9
0
0
0
17
0
9
0
9
% Q
% Arg:
0
0
0
9
0
17
0
0
0
9
34
0
9
9
0
% R
% Ser:
0
0
0
0
0
0
0
42
0
0
0
42
0
0
17
% S
% Thr:
9
0
0
0
0
9
0
9
0
0
0
0
0
0
0
% T
% Val:
0
0
0
67
0
0
0
0
17
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
84
0
% W
% Tyr:
0
9
0
0
0
0
0
9
0
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _