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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ENTPD5 All Species: 23.94
Human Site: S114 Identified Species: 47.88
UniProt: O75356 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75356 NP_001240.1 428 47517 S114 L L E V A K D S I P R S H W K
Chimpanzee Pan troglodytes XP_510057 428 47543 S114 L L E V A K D S I P R S H W K
Rhesus Macaque Macaca mulatta XP_001092475 428 47501 S114 L L E V A K D S I P R S H W K
Dog Lupus familis XP_853865 428 47445 S114 L L E V A K D S I P Q S H W K
Cat Felis silvestris
Mouse Mus musculus Q9WUZ9 427 47083 S113 L L E V A K D S I P R S H W E
Rat Rattus norvegicus Q9ER31 455 49881 H138 L L N V A K Q H I P Y D F W K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus O93295 493 54016 G125 T Y L G A T A G M R L L R E Q
Frog Xenopus laevis NP_001089154 468 52036 E153 L L N I A K K E I P Q K L W A
Zebra Danio Brachydanio rerio XP_684862 450 50634 T136 L L K V A K K T I P K E Q W I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_722860 464 51101 F147 L L D E A R A F I P K E H W S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9XU84 479 53825 E112 L L Q R A R K E V P H F M W E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32621 518 56803 Y156 L L K V A M N Y V P I K A R S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 97.6 92.7 N.A. 88 47 N.A. N.A. 29.6 44 53.1 N.A. 35.1 N.A. 32.7 N.A.
Protein Similarity: 100 99.7 98.8 96.7 N.A. 93.6 61.5 N.A. N.A. 43.6 58.7 70 N.A. 52.7 N.A. 49.2 N.A.
P-Site Identity: 100 100 100 93.3 N.A. 93.3 60 N.A. N.A. 6.6 46.6 53.3 N.A. 46.6 N.A. 33.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 60 N.A. N.A. 20 60 73.3 N.A. 66.6 N.A. 60 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 30.8 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 45.7 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 33.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 100 0 17 0 0 0 0 0 9 0 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 9 0 0 0 42 0 0 0 0 9 0 0 0 % D
% Glu: 0 0 42 9 0 0 0 17 0 0 0 17 0 9 17 % E
% Phe: 0 0 0 0 0 0 0 9 0 0 0 9 9 0 0 % F
% Gly: 0 0 0 9 0 0 0 9 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 9 0 0 9 0 50 0 0 % H
% Ile: 0 0 0 9 0 0 0 0 75 0 9 0 0 0 9 % I
% Lys: 0 0 17 0 0 67 25 0 0 0 17 17 0 0 42 % K
% Leu: 92 92 9 0 0 0 0 0 0 0 9 9 9 0 0 % L
% Met: 0 0 0 0 0 9 0 0 9 0 0 0 9 0 0 % M
% Asn: 0 0 17 0 0 0 9 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 92 0 0 0 0 0 % P
% Gln: 0 0 9 0 0 0 9 0 0 0 17 0 9 0 9 % Q
% Arg: 0 0 0 9 0 17 0 0 0 9 34 0 9 9 0 % R
% Ser: 0 0 0 0 0 0 0 42 0 0 0 42 0 0 17 % S
% Thr: 9 0 0 0 0 9 0 9 0 0 0 0 0 0 0 % T
% Val: 0 0 0 67 0 0 0 0 17 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 84 0 % W
% Tyr: 0 9 0 0 0 0 0 9 0 0 9 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _