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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ENTPD5 All Species: 26.97
Human Site: S165 Identified Species: 53.94
UniProt: O75356 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75356 NP_001240.1 428 47517 S165 L V P K G S V S I M D G S D E
Chimpanzee Pan troglodytes XP_510057 428 47543 S165 L V P K G S V S I M D G S D E
Rhesus Macaque Macaca mulatta XP_001092475 428 47501 S165 L V P K D S V S I M D G S D E
Dog Lupus familis XP_853865 428 47445 S165 L V P N D S V S I M D G S Y E
Cat Felis silvestris
Mouse Mus musculus Q9WUZ9 427 47083 S164 L V P D G S V S I M D G S Y E
Rat Rattus norvegicus Q9ER31 455 49881 S189 L V G D D C V S I M N G T D E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus O93295 493 54016 F169 T G N E E G S F G W I T V N Y
Frog Xenopus laevis NP_001089154 468 52036 S204 L I G K D S V S I M N G T D E
Zebra Danio Brachydanio rerio XP_684862 450 50634 T187 F V P N N S V T I M N G I N E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_722860 464 51101 E198 S V D M D A V E I M D G T D E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9XU84 479 53825 N164 A A F P D A V N V M P G S D E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32621 518 56803 M211 E G D G V S I M G G D E E G V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 97.6 92.7 N.A. 88 47 N.A. N.A. 29.6 44 53.1 N.A. 35.1 N.A. 32.7 N.A.
Protein Similarity: 100 99.7 98.8 96.7 N.A. 93.6 61.5 N.A. N.A. 43.6 58.7 70 N.A. 52.7 N.A. 49.2 N.A.
P-Site Identity: 100 100 93.3 80 N.A. 86.6 60 N.A. N.A. 0 66.6 53.3 N.A. 53.3 N.A. 40 N.A.
P-Site Similarity: 100 100 93.3 80 N.A. 86.6 73.3 N.A. N.A. 13.3 86.6 73.3 N.A. 66.6 N.A. 60 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 30.8 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 45.7 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 9 0 0 0 17 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 17 17 50 0 0 0 0 0 59 0 0 59 0 % D
% Glu: 9 0 0 9 9 0 0 9 0 0 0 9 9 0 84 % E
% Phe: 9 0 9 0 0 0 0 9 0 0 0 0 0 0 0 % F
% Gly: 0 17 17 9 25 9 0 0 17 9 0 84 0 9 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 9 0 0 0 0 9 0 75 0 9 0 9 0 0 % I
% Lys: 0 0 0 34 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 59 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 9 0 0 0 9 0 84 0 0 0 0 0 % M
% Asn: 0 0 9 17 9 0 0 9 0 0 25 0 0 17 0 % N
% Pro: 0 0 50 9 0 0 0 0 0 0 9 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 9 0 0 0 0 67 9 59 0 0 0 0 50 0 0 % S
% Thr: 9 0 0 0 0 0 0 9 0 0 0 9 25 0 0 % T
% Val: 0 67 0 0 9 0 84 0 9 0 0 0 9 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 17 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _