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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ENTPD5
All Species:
17.88
Human Site:
S371
Identified Species:
35.76
UniProt:
O75356
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75356
NP_001240.1
428
47517
S371
D
N
L
E
N
F
T
S
G
S
P
F
L
C
M
Chimpanzee
Pan troglodytes
XP_510057
428
47543
S371
D
N
L
E
N
F
T
S
G
S
P
F
L
C
M
Rhesus Macaque
Macaca mulatta
XP_001092475
428
47501
S371
D
N
L
E
N
F
T
S
G
S
P
F
L
C
M
Dog
Lupus familis
XP_853865
428
47445
S371
D
N
L
E
N
F
T
S
G
S
P
F
L
C
M
Cat
Felis silvestris
Mouse
Mus musculus
Q9WUZ9
427
47083
S370
D
N
L
G
S
F
S
S
G
S
P
F
L
C
M
Rat
Rattus norvegicus
Q9ER31
455
49881
P394
C
R
T
L
E
T
Q
P
P
S
S
P
F
A
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
O93295
493
54016
A431
N
I
H
F
S
Q
K
A
G
N
A
D
I
G
W
Frog
Xenopus laevis
NP_001089154
468
52036
G411
K
L
I
E
E
A
P
G
E
N
P
F
L
C
M
Zebra Danio
Brachydanio rerio
XP_684862
450
50634
P394
N
K
M
T
K
Y
R
P
I
S
P
Y
L
C
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_722860
464
51101
D405
E
I
C
A
I
P
N
D
E
Q
P
F
M
C
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9XU84
479
53825
H383
T
E
I
D
D
G
S
H
W
M
P
W
Q
C
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32621
518
56803
E456
A
G
S
L
D
E
L
E
S
D
S
H
F
C
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.6
92.7
N.A.
88
47
N.A.
N.A.
29.6
44
53.1
N.A.
35.1
N.A.
32.7
N.A.
Protein Similarity:
100
99.7
98.8
96.7
N.A.
93.6
61.5
N.A.
N.A.
43.6
58.7
70
N.A.
52.7
N.A.
49.2
N.A.
P-Site Identity:
100
100
100
100
N.A.
80
6.6
N.A.
N.A.
6.6
40
33.3
N.A.
20
N.A.
13.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
93.3
6.6
N.A.
N.A.
40
53.3
60
N.A.
33.3
N.A.
53.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
30.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
9
0
9
0
9
0
0
9
0
0
9
0
% A
% Cys:
9
0
9
0
0
0
0
0
0
0
0
0
0
84
9
% C
% Asp:
42
0
0
9
17
0
0
9
0
9
0
9
0
0
0
% D
% Glu:
9
9
0
42
17
9
0
9
17
0
0
0
0
0
0
% E
% Phe:
0
0
0
9
0
42
0
0
0
0
0
59
17
0
9
% F
% Gly:
0
9
0
9
0
9
0
9
50
0
0
0
0
9
0
% G
% His:
0
0
9
0
0
0
0
9
0
0
0
9
0
0
0
% H
% Ile:
0
17
17
0
9
0
0
0
9
0
0
0
9
0
0
% I
% Lys:
9
9
0
0
9
0
9
0
0
0
0
0
0
0
0
% K
% Leu:
0
9
42
17
0
0
9
0
0
0
0
0
59
0
17
% L
% Met:
0
0
9
0
0
0
0
0
0
9
0
0
9
0
59
% M
% Asn:
17
42
0
0
34
0
9
0
0
17
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
9
9
17
9
0
75
9
0
0
0
% P
% Gln:
0
0
0
0
0
9
9
0
0
9
0
0
9
0
0
% Q
% Arg:
0
9
0
0
0
0
9
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
9
0
17
0
17
42
9
59
17
0
0
0
0
% S
% Thr:
9
0
9
9
0
9
34
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
9
0
0
9
0
0
9
% W
% Tyr:
0
0
0
0
0
9
0
0
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _