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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ENTPD5
All Species:
17.88
Human Site:
T267
Identified Species:
35.76
UniProt:
O75356
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75356
NP_001240.1
428
47517
T267
T
E
G
T
D
G
H
T
F
R
S
A
C
L
P
Chimpanzee
Pan troglodytes
XP_510057
428
47543
T267
T
E
G
T
D
G
H
T
F
R
S
A
C
L
P
Rhesus Macaque
Macaca mulatta
XP_001092475
428
47501
T267
T
E
G
T
D
G
H
T
F
R
S
A
C
L
P
Dog
Lupus familis
XP_853865
428
47445
T267
T
E
G
I
D
G
H
T
F
R
S
A
C
L
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9WUZ9
427
47083
T266
A
K
G
T
D
G
H
T
F
R
S
A
C
L
P
Rat
Rattus norvegicus
Q9ER31
455
49881
K291
G
K
P
A
E
D
D
K
E
L
V
S
P
C
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
O93295
493
54016
P271
Y
V
Q
N
I
S
H
P
C
Y
P
K
G
Y
R
Frog
Xenopus laevis
NP_001089154
468
52036
E306
G
K
S
L
Q
E
G
E
Q
L
V
T
S
C
L
Zebra Danio
Brachydanio rerio
XP_684862
450
50634
V289
A
D
G
L
E
W
K
V
F
R
S
S
C
L
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_722860
464
51101
C300
D
T
V
L
E
S
V
C
V
N
P
I
I
A
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9XU84
479
53825
T266
L
N
I
L
Q
L
E
T
D
N
E
I
E
S
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32621
518
56803
K313
E
N
A
L
K
D
G
K
I
L
K
G
D
N
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.6
92.7
N.A.
88
47
N.A.
N.A.
29.6
44
53.1
N.A.
35.1
N.A.
32.7
N.A.
Protein Similarity:
100
99.7
98.8
96.7
N.A.
93.6
61.5
N.A.
N.A.
43.6
58.7
70
N.A.
52.7
N.A.
49.2
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
86.6
0
N.A.
N.A.
6.6
0
46.6
N.A.
0
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
20
N.A.
N.A.
6.6
6.6
66.6
N.A.
6.6
N.A.
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
30.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
0
9
9
0
0
0
0
0
0
0
42
0
9
0
% A
% Cys:
0
0
0
0
0
0
0
9
9
0
0
0
50
17
0
% C
% Asp:
9
9
0
0
42
17
9
0
9
0
0
0
9
0
0
% D
% Glu:
9
34
0
0
25
9
9
9
9
0
9
0
9
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
50
0
0
0
0
0
0
% F
% Gly:
17
0
50
0
0
42
17
0
0
0
0
9
9
0
0
% G
% His:
0
0
0
0
0
0
50
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
9
9
9
0
0
0
9
0
0
17
9
0
0
% I
% Lys:
0
25
0
0
9
0
9
17
0
0
9
9
0
0
0
% K
% Leu:
9
0
0
42
0
9
0
0
0
25
0
0
0
50
17
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
17
0
9
0
0
0
0
0
17
0
0
0
9
9
% N
% Pro:
0
0
9
0
0
0
0
9
0
0
17
0
9
0
50
% P
% Gln:
0
0
9
0
17
0
0
0
9
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
50
0
0
0
0
9
% R
% Ser:
0
0
9
0
0
17
0
0
0
0
50
17
9
9
0
% S
% Thr:
34
9
0
34
0
0
0
50
0
0
0
9
0
0
17
% T
% Val:
0
9
9
0
0
0
9
9
9
0
17
0
0
0
0
% V
% Trp:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
0
0
0
0
0
9
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _