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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AVIL All Species: 20.3
Human Site: S53 Identified Species: 40.61
UniProt: O75366 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75366 NP_006567.2 819 92028 S53 L S T R R V A S L L S Q D I H
Chimpanzee Pan troglodytes XP_509177 819 92037 S53 L S T R R V A S L L S Q D I H
Rhesus Macaque Macaca mulatta XP_001101627 837 93554 S71 L S T R R V A S L L S Q D I H
Dog Lupus familis XP_531652 817 91548 S54 L S T R R A G S L L S Q D I H
Cat Felis silvestris
Mouse Mus musculus O88398 819 92168 S53 L S T R R V G S L L S Q N I H
Rat Rattus norvegicus Q68FP1 780 86049 G104 K T V Q L R N G N L Q Y D L H
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P02640 826 92461 S56 L S T R K T G S G F S Y N I H
Frog Xenopus laevis P14885 417 46006
Zebra Danio Brachydanio rerio NP_001035455 811 90971 K51 L S T C K S G K T I S Y D I H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q07171 798 88356 K111 T I E N K K D K K L S W D V H
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus NP_001107669 831 93189 N54 L K T N K K G N G F S Y N I H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O81645 966 106448 G59 Q T T Q N K G G A Y L F D I H
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 93.3 88.2 N.A. 89.1 42.7 N.A. N.A. 62.9 26.7 63.7 N.A. 33.9 N.A. N.A. 44.2
Protein Similarity: 100 99.3 95.2 93.5 N.A. 94.5 56.5 N.A. N.A. 77.2 35.4 78.5 N.A. 50.9 N.A. N.A. 64.3
P-Site Identity: 100 100 100 86.6 N.A. 86.6 20 N.A. N.A. 53.3 0 46.6 N.A. 26.6 N.A. N.A. 33.3
P-Site Similarity: 100 100 100 86.6 N.A. 93.3 40 N.A. N.A. 66.6 0 60 N.A. 40 N.A. N.A. 53.3
Percent
Protein Identity: N.A. N.A. N.A. 31.8 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 47.1 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 26.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 40 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 9 25 0 9 0 0 0 0 0 0 % A
% Cys: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 9 0 0 0 0 0 67 0 0 % D
% Glu: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 17 0 9 0 0 0 % F
% Gly: 0 0 0 0 0 0 50 17 17 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 92 % H
% Ile: 0 9 0 0 0 0 0 0 0 9 0 0 0 75 0 % I
% Lys: 9 9 0 0 34 25 0 17 9 0 0 0 0 0 0 % K
% Leu: 67 0 0 0 9 0 0 0 42 59 9 0 0 9 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 17 9 0 9 9 9 0 0 0 25 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 9 0 0 17 0 0 0 0 0 0 9 42 0 0 0 % Q
% Arg: 0 0 0 50 42 9 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 59 0 0 0 9 0 50 0 0 75 0 0 0 0 % S
% Thr: 9 17 75 0 0 9 0 0 9 0 0 0 0 0 0 % T
% Val: 0 0 9 0 0 34 0 0 0 0 0 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 9 0 34 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _