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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AVIL All Species: 28.48
Human Site: Y253 Identified Species: 56.97
UniProt: O75366 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75366 NP_006567.2 819 92028 Y253 Q K S T I M L Y H I S D S A G
Chimpanzee Pan troglodytes XP_509177 819 92037 Y253 Q K S T I M L Y H I S D S A G
Rhesus Macaque Macaca mulatta XP_001101627 837 93554 Y271 Q K S N I M L Y H V S D S P G
Dog Lupus familis XP_531652 817 91548 Y254 Q N S S I V L Y H V S D A A G
Cat Felis silvestris
Mouse Mus musculus O88398 819 92168 Y253 Q K S S I M L Y H V S D T A G
Rat Rattus norvegicus Q68FP1 780 86049 P276 L Q V L G P K P D L P Q G T E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P02640 826 92461 Y256 L N S A L K L Y H V S D A S G
Frog Xenopus laevis P14885 417 46006
Zebra Danio Brachydanio rerio NP_001035455 811 90971 Y252 Q M A K L T L Y H V S D A N G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q07171 798 88356 S284 H F F D V L G S G S A D Q V P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus NP_001107669 831 93189 Y256 Q A A Q T R L Y K V S D E S G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O81645 966 106448 T251 E D E I I P E T T P P K L Y S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 93.3 88.2 N.A. 89.1 42.7 N.A. N.A. 62.9 26.7 63.7 N.A. 33.9 N.A. N.A. 44.2
Protein Similarity: 100 99.3 95.2 93.5 N.A. 94.5 56.5 N.A. N.A. 77.2 35.4 78.5 N.A. 50.9 N.A. N.A. 64.3
P-Site Identity: 100 100 80 66.6 N.A. 80 0 N.A. N.A. 46.6 0 46.6 N.A. 6.6 N.A. N.A. 40
P-Site Similarity: 100 100 86.6 93.3 N.A. 100 13.3 N.A. N.A. 73.3 0 73.3 N.A. 26.6 N.A. N.A. 60
Percent
Protein Identity: N.A. N.A. N.A. 31.8 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 47.1 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 17 9 0 0 0 0 0 0 9 0 25 34 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 9 0 9 0 0 0 0 9 0 0 75 0 0 0 % D
% Glu: 9 0 9 0 0 0 9 0 0 0 0 0 9 0 9 % E
% Phe: 0 9 9 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 9 0 9 0 9 0 0 0 9 0 67 % G
% His: 9 0 0 0 0 0 0 0 59 0 0 0 0 0 0 % H
% Ile: 0 0 0 9 50 0 0 0 0 17 0 0 0 0 0 % I
% Lys: 0 34 0 9 0 9 9 0 9 0 0 9 0 0 0 % K
% Leu: 17 0 0 9 17 9 67 0 0 9 0 0 9 0 0 % L
% Met: 0 9 0 0 0 34 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 17 0 9 0 0 0 0 0 0 0 0 0 9 0 % N
% Pro: 0 0 0 0 0 17 0 9 0 9 17 0 0 9 9 % P
% Gln: 59 9 0 9 0 0 0 0 0 0 0 9 9 0 0 % Q
% Arg: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 50 17 0 0 0 9 0 9 67 0 25 17 9 % S
% Thr: 0 0 0 17 9 9 0 9 9 0 0 0 9 9 0 % T
% Val: 0 0 9 0 9 9 0 0 0 50 0 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 67 0 0 0 0 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _