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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ULK1 All Species: 3.94
Human Site: S422 Identified Species: 7.22
UniProt: O75385 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.33
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75385 NP_003556.1 1050 112601 S422 S G R A G P F S S S R C G A S
Chimpanzee Pan troglodytes XP_001148902 1004 106920 V380 A Q F P G D L V A E A P S A K
Rhesus Macaque Macaca mulatta XP_001105326 958 102155 R354 Q N Y Q R I E R N L Q S P T Q
Dog Lupus familis XP_534635 1032 110603 F402 P S G R A G P F S S R C G V S
Cat Felis silvestris
Mouse Mus musculus O70405 1051 112444 S422 S G R P G P F S S N R Y G A S
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508434 1038 113312 R395 C Q P S L S P R S E T A P I P
Chicken Gallus gallus Q5ZJH6 468 53047
Frog Xenopus laevis Q4V7Q6 468 53109
Zebra Danio Brachydanio rerio XP_002665971 974 105808 R368 S Q G K T P P R S P S F S S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648601 835 90628 Q231 E L K S Y Y E Q N A N L A P K
Honey Bee Apis mellifera XP_624950 752 82281 K148 L L S H N C G K A C P Q P H Q
Nematode Worm Caenorhab. elegans Q23023 856 94874 L252 S P N L R D L L L R L L K R N
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7RX99 932 102644 V328 E D L F N H P V V T E P I P G
Conservation
Percent
Protein Identity: 100 84.2 89.1 87.9 N.A. 89.8 N.A. N.A. 52.1 22.4 22 57.3 N.A. 34.3 36.6 33.6 N.A.
Protein Similarity: 100 86.1 89.7 91.2 N.A. 92.7 N.A. N.A. 63.9 31.8 31.7 69.1 N.A. 47.7 49.3 47.9 N.A.
P-Site Identity: 100 13.3 0 40 N.A. 80 N.A. N.A. 6.6 0 0 26.6 N.A. 0 0 6.6 N.A.
P-Site Similarity: 100 26.6 13.3 40 N.A. 86.6 N.A. N.A. 13.3 0 0 33.3 N.A. 26.6 6.6 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 20
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 35.1
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 0
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 8 8 0 0 0 16 8 8 8 8 24 0 % A
% Cys: 8 0 0 0 0 8 0 0 0 8 0 16 0 0 0 % C
% Asp: 0 8 0 0 0 16 0 0 0 0 0 0 0 0 0 % D
% Glu: 16 0 0 0 0 0 16 0 0 16 8 0 0 0 0 % E
% Phe: 0 0 8 8 0 0 16 8 0 0 0 8 0 0 0 % F
% Gly: 0 16 16 0 24 8 8 0 0 0 0 0 24 0 8 % G
% His: 0 0 0 8 0 8 0 0 0 0 0 0 0 8 0 % H
% Ile: 0 0 0 0 0 8 0 0 0 0 0 0 8 8 0 % I
% Lys: 0 0 8 8 0 0 0 8 0 0 0 0 8 0 16 % K
% Leu: 8 16 8 8 8 0 16 8 8 8 8 16 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 8 0 16 0 0 0 16 8 8 0 0 0 8 % N
% Pro: 8 8 8 16 0 24 31 0 0 8 8 16 24 16 8 % P
% Gln: 8 24 0 8 0 0 0 8 0 0 8 8 0 0 16 % Q
% Arg: 0 0 16 8 16 0 0 24 0 8 24 0 0 8 0 % R
% Ser: 31 8 8 16 0 8 0 16 39 16 8 8 16 8 31 % S
% Thr: 0 0 0 0 8 0 0 0 0 8 8 0 0 8 0 % T
% Val: 0 0 0 0 0 0 0 16 8 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 8 8 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _