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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CS All Species: 36.36
Human Site: S453 Identified Species: 61.54
UniProt: O75390 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.23
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75390 NP_004068.2 466 51712 S453 L E R P K S M S T E G L M K F
Chimpanzee Pan troglodytes XP_001153202 466 51724 S453 L E R P K S M S T E G L M K F
Rhesus Macaque Macaca mulatta XP_001098147 621 67563 S608 L E R P K S M S T E G L M K F
Dog Lupus familis XP_531634 466 51770 S453 L E R P K S M S T D G L M K F
Cat Felis silvestris
Mouse Mus musculus Q9CZU6 464 51718 E447 R A L G F P L E R P K S M S T
Rat Rattus norvegicus Q8VHF5 466 51848 S453 L E R P K S M S T D G L M K F
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P23007 433 47314 E420 R A L G F P L E R P K S M S T
Frog Xenopus laevis Q7ZWZ5 468 51729 S455 L E R P K S M S T D G L M Q L
Zebra Danio Brachydanio rerio Q7ZVY5 468 51733 S455 L E R P K S M S T D G L M A L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W401 464 51556 E448 R A L G L P I E R P K S F S T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34575 468 51522 S455 L E R P K S H S T D G L I K L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P20115 474 52764 T460 L E R P K S V T M D W L E A H
Baker's Yeast Sacchar. cerevisiae P00890 479 53342 S464 I E R P K S F S T E K Y K E L
Red Bread Mold Neurospora crassa P34085 469 51970 P450 I D R A V G A P I E R P K S Y
Conservation
Percent
Protein Identity: 100 99.7 74.2 96.7 N.A. 93.9 94.6 N.A. N.A. 83.6 88 87.6 N.A. 70.1 N.A. 67.3 N.A.
Protein Similarity: 100 99.7 74.5 98 N.A. 97.4 97.8 N.A. N.A. 86 95.3 95.3 N.A. 81.3 N.A. 80.7 N.A.
P-Site Identity: 100 100 100 93.3 N.A. 6.6 93.3 N.A. N.A. 6.6 80 80 N.A. 0 N.A. 73.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 13.3 100 N.A. N.A. 13.3 93.3 86.6 N.A. 6.6 N.A. 86.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 58.6 59.7 60.7
Protein Similarity: N.A. N.A. N.A. 75.7 76.6 78.4
P-Site Identity: N.A. N.A. N.A. 46.6 53.3 13.3
P-Site Similarity: N.A. N.A. N.A. 66.6 66.6 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 22 0 8 0 0 8 0 0 0 0 0 0 15 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 0 0 0 0 0 43 0 0 0 0 0 % D
% Glu: 0 72 0 0 0 0 0 22 0 36 0 0 8 8 0 % E
% Phe: 0 0 0 0 15 0 8 0 0 0 0 0 8 0 36 % F
% Gly: 0 0 0 22 0 8 0 0 0 0 58 0 0 0 0 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 8 % H
% Ile: 15 0 0 0 0 0 8 0 8 0 0 0 8 0 0 % I
% Lys: 0 0 0 0 72 0 0 0 0 0 29 0 15 43 0 % K
% Leu: 65 0 22 0 8 0 15 0 0 0 0 65 0 0 29 % L
% Met: 0 0 0 0 0 0 50 0 8 0 0 0 65 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 72 0 22 0 8 0 22 0 8 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % Q
% Arg: 22 0 79 0 0 0 0 0 22 0 8 0 0 0 0 % R
% Ser: 0 0 0 0 0 72 0 65 0 0 0 22 0 29 0 % S
% Thr: 0 0 0 0 0 0 0 8 65 0 0 0 0 0 22 % T
% Val: 0 0 0 0 8 0 8 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _