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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRPF40A All Species: 20.3
Human Site: S479 Identified Species: 37.22
UniProt: O75400 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75400 NP_060362.3 957 108805 S479 E N H E K M T S T T R Y K K A
Chimpanzee Pan troglodytes XP_515837 972 110432 S494 E N H E K M T S T T R Y K K A
Rhesus Macaque Macaca mulatta XP_001101626 863 97737 A434 D D V L F F L A K K E K E Q A
Dog Lupus familis XP_533359 874 99942 K434 D V L F F L S K K E K E Q A K
Cat Felis silvestris
Mouse Mus musculus Q9R1C7 953 108462 S475 E N H E K M T S T T R Y K K A
Rat Rattus norvegicus NP_001099950 953 108455 S475 E N H E K M T S T T R Y K K A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508338 855 97709 R444 V W N A I S E R D R L E I Y E
Chicken Gallus gallus NP_989492 853 96992 E449 R D R L E I Y E D V L F F L S
Frog Xenopus laevis NP_001121292 487 54707 P91 T H V S Q G L P P S M Q A A V
Zebra Danio Brachydanio rerio NP_938170 851 97677 Y440 D N M A N V T Y R T T W S E A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_608738 806 91309 D409 D V T L L G M D K E D A L I V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34600 724 84646 E328 A S D I F S K E P L W I A V N
Sea Urchin Strong. purpuratus XP_001178122 1501 164734 S758 Q H H P K M T S T T R Y R K A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 51.8 89.6 N.A. 96 96.2 N.A. 74.4 70.9 30.2 66 N.A. 41.1 N.A. 30.5 35.3
Protein Similarity: 100 98 65.6 90.6 N.A. 97.5 97.3 N.A. 78.4 75.4 36.5 74.6 N.A. 57.2 N.A. 50.2 46.5
P-Site Identity: 100 100 6.6 0 N.A. 100 100 N.A. 0 0 0 26.6 N.A. 0 N.A. 0 73.3
P-Site Similarity: 100 100 40 33.3 N.A. 100 100 N.A. 6.6 33.3 20 53.3 N.A. 6.6 N.A. 6.6 93.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 16 0 0 0 8 0 0 0 8 16 16 54 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 31 16 8 0 0 0 0 8 16 0 8 0 0 0 0 % D
% Glu: 31 0 0 31 8 0 8 16 0 16 8 16 8 8 8 % E
% Phe: 0 0 0 8 24 8 0 0 0 0 0 8 8 0 0 % F
% Gly: 0 0 0 0 0 16 0 0 0 0 0 0 0 0 0 % G
% His: 0 16 39 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 8 8 0 0 0 0 0 8 8 8 0 % I
% Lys: 0 0 0 0 39 0 8 8 24 8 8 8 31 39 8 % K
% Leu: 0 0 8 24 8 8 16 0 0 8 16 0 8 8 0 % L
% Met: 0 0 8 0 0 39 8 0 0 0 8 0 0 0 0 % M
% Asn: 0 39 8 0 8 0 0 0 0 0 0 0 0 0 8 % N
% Pro: 0 0 0 8 0 0 0 8 16 0 0 0 0 0 0 % P
% Gln: 8 0 0 0 8 0 0 0 0 0 0 8 8 8 0 % Q
% Arg: 8 0 8 0 0 0 0 8 8 8 39 0 8 0 0 % R
% Ser: 0 8 0 8 0 16 8 39 0 8 0 0 8 0 8 % S
% Thr: 8 0 8 0 0 0 47 0 39 47 8 0 0 0 0 % T
% Val: 8 16 16 0 0 8 0 0 0 8 0 0 0 8 16 % V
% Trp: 0 8 0 0 0 0 0 0 0 0 8 8 0 0 0 % W
% Tyr: 0 0 0 0 0 0 8 8 0 0 0 39 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _