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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF40A
All Species:
24.85
Human Site:
S599
Identified Species:
45.56
UniProt:
O75400
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75400
NP_060362.3
957
108805
S599
E
E
E
E
K
Q
K
S
L
L
R
E
R
R
R
Chimpanzee
Pan troglodytes
XP_515837
972
110432
S614
E
E
E
E
K
Q
K
S
L
L
R
E
R
R
R
Rhesus Macaque
Macaca mulatta
XP_001101626
863
97737
A517
E
E
E
E
R
E
R
A
R
L
R
E
R
R
Q
Dog
Lupus familis
XP_533359
874
99942
S516
E
E
E
E
K
Q
K
S
L
L
R
E
R
R
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9R1C7
953
108462
T595
E
E
E
E
K
Q
K
T
L
L
R
E
R
R
R
Rat
Rattus norvegicus
NP_001099950
953
108455
T595
E
E
E
E
K
Q
K
T
L
L
R
E
R
R
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508338
855
97709
K532
E
H
I
R
A
L
E
K
E
E
E
E
E
K
Q
Chicken
Gallus gallus
NP_989492
853
96992
S539
E
E
E
E
K
Q
K
S
L
L
R
E
R
R
R
Frog
Xenopus laevis
NP_001121292
487
54707
I173
P
D
D
M
K
T
P
I
E
Q
L
L
S
K
C
Zebra Danio
Brachydanio rerio
NP_938170
851
97677
S525
H
G
Q
L
H
S
M
S
A
W
M
E
M
Y
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608738
806
91309
S491
A
M
L
G
Q
S
G
S
T
P
L
D
L
F
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34600
724
84646
E410
D
L
H
F
M
D
K
E
D
A
L
T
V
F
E
Sea Urchin
Strong. purpuratus
XP_001178122
1501
164734
A878
E
E
D
E
L
E
R
A
K
M
L
K
K
R
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
51.8
89.6
N.A.
96
96.2
N.A.
74.4
70.9
30.2
66
N.A.
41.1
N.A.
30.5
35.3
Protein Similarity:
100
98
65.6
90.6
N.A.
97.5
97.3
N.A.
78.4
75.4
36.5
74.6
N.A.
57.2
N.A.
50.2
46.5
P-Site Identity:
100
100
60
100
N.A.
93.3
93.3
N.A.
13.3
100
6.6
13.3
N.A.
6.6
N.A.
6.6
26.6
P-Site Similarity:
100
100
93.3
100
N.A.
100
100
N.A.
33.3
100
26.6
20
N.A.
26.6
N.A.
13.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
0
0
16
8
8
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
8
8
16
0
0
8
0
0
8
0
0
8
0
0
0
% D
% Glu:
70
62
54
62
0
16
8
8
16
8
8
70
8
0
8
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
0
0
0
16
0
% F
% Gly:
0
8
0
8
0
0
8
0
0
0
0
0
0
0
0
% G
% His:
8
8
8
0
8
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
54
0
54
8
8
0
0
8
8
16
8
% K
% Leu:
0
8
8
8
8
8
0
0
47
54
31
8
8
0
0
% L
% Met:
0
8
0
8
8
0
8
0
0
8
8
0
8
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
8
0
0
0
0
0
8
0
0
8
0
0
0
0
8
% P
% Gln:
0
0
8
0
8
47
0
0
0
8
0
0
0
0
16
% Q
% Arg:
0
0
0
8
8
0
16
0
8
0
54
0
54
62
47
% R
% Ser:
0
0
0
0
0
16
0
47
0
0
0
0
8
0
0
% S
% Thr:
0
0
0
0
0
8
0
16
8
0
0
8
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _