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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC45L
All Species:
25.15
Human Site:
S144
Identified Species:
42.56
UniProt:
O75419
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75419
NP_003495.1
566
65569
S144
E
E
E
D
E
E
H
S
G
N
D
S
D
G
S
Chimpanzee
Pan troglodytes
XP_514980
566
65532
S144
E
E
E
D
E
E
H
S
G
N
D
S
D
G
S
Rhesus Macaque
Macaca mulatta
XP_001104872
566
65509
S144
E
E
E
D
E
E
H
S
G
N
D
S
D
G
S
Dog
Lupus familis
XP_543547
586
67352
G164
E
E
A
E
E
H
S
G
S
E
S
D
N
G
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z1X9
566
65366
S144
E
A
E
D
E
D
L
S
D
S
D
G
D
G
S
Rat
Rattus norvegicus
NP_001099336
570
65921
L144
E
A
E
D
E
E
D
L
S
E
N
D
D
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_415070
566
65691
S144
E
E
D
E
E
E
D
S
E
N
E
S
D
G
S
Frog
Xenopus laevis
Q9YHZ6
567
65426
S144
D
E
E
D
G
E
D
S
G
N
E
S
D
G
A
Zebra Danio
Brachydanio rerio
NP_998551
572
65871
D144
D
E
E
D
E
E
A
D
G
D
D
S
G
N
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569880
575
65872
E144
S
E
G
E
D
E
D
E
D
E
S
S
D
T
E
Honey Bee
Apis mellifera
XP_393560
561
64352
T142
D
S
S
D
E
S
E
T
N
E
E
L
D
N
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001180929
568
65050
S144
D
E
S
D
S
D
D
S
G
A
E
S
D
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_189146
596
67533
A167
F
Q
L
R
V
E
D
A
G
E
E
S
D
E
E
Baker's Yeast
Sacchar. cerevisiae
Q08032
650
74231
N182
S
G
D
E
N
D
N
N
G
G
D
D
E
A
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.2
90.2
N.A.
91.6
91
N.A.
N.A.
83.2
78.3
74.3
N.A.
40
43.4
N.A.
55.4
Protein Similarity:
100
100
99.6
94.3
N.A.
95.9
95.2
N.A.
N.A.
94.1
90.4
90.3
N.A.
64.8
64.4
N.A.
75.1
P-Site Identity:
100
100
100
33.3
N.A.
60
46.6
N.A.
N.A.
66.6
66.6
53.3
N.A.
26.6
20
N.A.
46.6
P-Site Similarity:
100
100
100
46.6
N.A.
73.3
53.3
N.A.
N.A.
86.6
86.6
66.6
N.A.
40
40
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
30.3
26.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.5
48.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
8
0
0
0
8
8
0
8
0
0
0
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
29
0
15
65
8
22
43
8
15
8
43
22
79
0
8
% D
% Glu:
50
65
50
29
65
65
8
8
8
36
36
0
8
8
22
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
8
0
8
0
0
8
58
8
0
8
8
58
8
% G
% His:
0
0
0
0
0
8
22
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
8
0
0
0
8
8
0
0
0
8
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
8
8
8
36
8
0
8
15
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
15
8
15
0
8
8
8
50
15
8
15
65
0
8
50
% S
% Thr:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
8
% T
% Val:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _