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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC45L
All Species:
40.61
Human Site:
S250
Identified Species:
68.72
UniProt:
O75419
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75419
NP_003495.1
566
65569
S250
G
V
L
Q
R
H
V
S
R
H
N
H
R
N
E
Chimpanzee
Pan troglodytes
XP_514980
566
65532
S250
G
V
L
Q
R
H
V
S
R
H
N
H
R
N
E
Rhesus Macaque
Macaca mulatta
XP_001104872
566
65509
S250
G
V
L
Q
R
H
V
S
R
H
N
H
R
N
E
Dog
Lupus familis
XP_543547
586
67352
S270
G
I
L
Q
R
H
V
S
R
H
N
H
R
N
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z1X9
566
65366
S250
G
I
L
Q
R
H
V
S
R
H
N
H
R
N
E
Rat
Rattus norvegicus
NP_001099336
570
65921
S254
G
V
L
Q
R
H
V
S
R
H
N
H
R
N
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_415070
566
65691
S250
G
I
L
Q
R
H
V
S
R
H
N
H
R
N
E
Frog
Xenopus laevis
Q9YHZ6
567
65426
S251
G
T
L
Q
R
H
V
S
R
H
N
H
G
N
E
Zebra Danio
Brachydanio rerio
NP_998551
572
65871
S256
A
T
L
Q
R
H
V
S
R
H
N
H
K
N
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569880
575
65872
S266
E
Q
I
Q
S
H
V
S
R
L
T
N
K
T
N
Honey Bee
Apis mellifera
XP_393560
561
64352
S245
G
F
L
Q
A
H
V
S
R
L
S
H
K
Q
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001180929
568
65050
A251
T
E
L
N
R
H
V
A
R
H
N
H
R
G
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_189146
596
67533
N276
M
E
L
E
Q
H
I
N
S
S
G
N
I
D
K
Baker's Yeast
Sacchar. cerevisiae
Q08032
650
74231
E298
L
Y
P
L
L
Q
D
E
V
K
R
L
T
P
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.2
90.2
N.A.
91.6
91
N.A.
N.A.
83.2
78.3
74.3
N.A.
40
43.4
N.A.
55.4
Protein Similarity:
100
100
99.6
94.3
N.A.
95.9
95.2
N.A.
N.A.
94.1
90.4
90.3
N.A.
64.8
64.4
N.A.
75.1
P-Site Identity:
100
100
100
93.3
N.A.
93.3
100
N.A.
N.A.
93.3
86.6
80
N.A.
33.3
53.3
N.A.
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
86.6
86.6
N.A.
53.3
66.6
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
30.3
26.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.5
48.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
0
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% D
% Glu:
8
15
0
8
0
0
0
8
0
0
0
0
0
0
72
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
65
0
0
0
0
0
0
0
0
0
8
0
8
8
8
% G
% His:
0
0
0
0
0
93
0
0
0
72
0
79
0
0
0
% H
% Ile:
0
22
8
0
0
0
8
0
0
0
0
0
8
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
8
0
0
22
0
8
% K
% Leu:
8
0
86
8
8
0
0
0
0
15
0
8
0
0
0
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
0
8
0
0
72
15
0
65
8
% N
% Pro:
0
0
8
0
0
0
0
0
0
0
0
0
0
8
0
% P
% Gln:
0
8
0
79
8
8
0
0
0
0
0
0
0
8
0
% Q
% Arg:
0
0
0
0
72
0
0
0
86
0
8
0
58
0
0
% R
% Ser:
0
0
0
0
8
0
0
79
8
8
8
0
0
0
8
% S
% Thr:
8
15
0
0
0
0
0
0
0
0
8
0
8
8
0
% T
% Val:
0
29
0
0
0
0
86
0
8
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _