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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC45L
All Species:
40.91
Human Site:
S335
Identified Species:
69.23
UniProt:
O75419
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75419
NP_003495.1
566
65569
S335
K
F
Q
A
M
D
I
S
L
K
E
N
L
R
E
Chimpanzee
Pan troglodytes
XP_514980
566
65532
S335
K
F
Q
A
M
D
I
S
L
K
E
N
L
R
E
Rhesus Macaque
Macaca mulatta
XP_001104872
566
65509
S335
K
F
Q
A
M
D
I
S
L
K
E
N
L
R
E
Dog
Lupus familis
XP_543547
586
67352
S355
K
F
Q
S
M
D
I
S
L
K
E
N
L
R
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z1X9
566
65366
S335
K
F
Q
S
M
D
V
S
L
K
G
N
L
R
E
Rat
Rattus norvegicus
NP_001099336
570
65921
S339
K
F
Q
S
M
D
V
S
L
K
E
N
L
R
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_415070
566
65691
S335
K
F
N
S
M
D
V
S
L
K
E
N
L
R
E
Frog
Xenopus laevis
Q9YHZ6
567
65426
S336
K
F
N
S
M
D
I
S
L
K
E
N
L
R
E
Zebra Danio
Brachydanio rerio
NP_998551
572
65871
T341
K
F
N
S
M
D
M
T
I
K
E
N
L
R
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569880
575
65872
V348
T
Y
G
A
M
D
L
V
L
R
K
E
F
F
S
Honey Bee
Apis mellifera
XP_393560
561
64352
A331
R
F
S
A
M
D
L
A
L
R
Q
E
L
R
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001180929
568
65050
T336
K
F
S
A
M
D
I
T
Y
K
N
S
I
R
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_189146
596
67533
E368
K
F
P
Y
M
S
L
E
V
K
R
K
M
K
Q
Baker's Yeast
Sacchar. cerevisiae
Q08032
650
74231
S383
T
W
L
Y
M
D
H
S
I
K
R
E
L
G
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.2
90.2
N.A.
91.6
91
N.A.
N.A.
83.2
78.3
74.3
N.A.
40
43.4
N.A.
55.4
Protein Similarity:
100
100
99.6
94.3
N.A.
95.9
95.2
N.A.
N.A.
94.1
90.4
90.3
N.A.
64.8
64.4
N.A.
75.1
P-Site Identity:
100
100
100
93.3
N.A.
80
86.6
N.A.
N.A.
80
86.6
66.6
N.A.
26.6
46.6
N.A.
60
P-Site Similarity:
100
100
100
100
N.A.
93.3
100
N.A.
N.A.
93.3
93.3
93.3
N.A.
53.3
86.6
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
30.3
26.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.5
48.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
43
0
0
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
93
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
8
0
0
58
22
0
0
72
% E
% Phe:
0
86
0
0
0
0
0
0
0
0
0
0
8
8
0
% F
% Gly:
0
0
8
0
0
0
0
0
0
0
8
0
0
8
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
43
0
15
0
0
0
8
0
8
% I
% Lys:
79
0
0
0
0
0
0
0
0
86
8
8
0
8
0
% K
% Leu:
0
0
8
0
0
0
22
0
72
0
0
0
79
0
0
% L
% Met:
0
0
0
0
100
0
8
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
22
0
0
0
0
0
0
0
8
65
0
0
0
% N
% Pro:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
43
0
0
0
0
0
0
0
8
0
0
0
15
% Q
% Arg:
8
0
0
0
0
0
0
0
0
15
15
0
0
79
0
% R
% Ser:
0
0
15
43
0
8
0
65
0
0
0
8
0
0
8
% S
% Thr:
15
0
0
0
0
0
0
15
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
22
8
8
0
0
0
0
0
0
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
15
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _