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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC45L
All Species:
28.48
Human Site:
S386
Identified Species:
48.21
UniProt:
O75419
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75419
NP_003495.1
566
65569
S386
A
T
M
S
L
M
E
S
P
E
K
D
G
S
G
Chimpanzee
Pan troglodytes
XP_514980
566
65532
S386
A
T
M
S
L
M
E
S
P
E
K
D
G
S
G
Rhesus Macaque
Macaca mulatta
XP_001104872
566
65509
S386
A
T
M
S
L
M
E
S
P
E
R
D
G
S
G
Dog
Lupus familis
XP_543547
586
67352
S406
A
T
M
S
L
M
E
S
P
E
K
D
D
S
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z1X9
566
65366
S386
A
T
M
S
L
M
E
S
P
E
K
D
G
S
G
Rat
Rattus norvegicus
NP_001099336
570
65921
R390
A
T
M
S
L
M
E
R
P
E
K
D
G
S
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_415070
566
65691
N386
A
T
A
S
L
M
E
N
I
E
K
E
G
P
E
Frog
Xenopus laevis
Q9YHZ6
567
65426
N387
A
V
L
S
L
L
E
N
T
E
R
D
E
K
G
Zebra Danio
Brachydanio rerio
NP_998551
572
65871
N392
A
A
A
A
L
L
E
N
V
E
K
D
E
T
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569880
575
65872
S399
A
L
L
A
I
M
E
S
V
K
K
H
K
T
P
Honey Bee
Apis mellifera
XP_393560
561
64352
S382
A
M
L
A
L
M
E
S
S
S
K
E
K
L
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001180929
568
65050
S387
A
V
E
A
I
L
E
S
V
D
K
N
K
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_189146
596
67533
S419
G
I
T
A
L
L
E
S
F
L
G
S
G
G
S
Baker's Yeast
Sacchar. cerevisiae
Q08032
650
74231
V434
A
L
T
A
L
L
E
V
G
N
S
T
D
K
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.2
90.2
N.A.
91.6
91
N.A.
N.A.
83.2
78.3
74.3
N.A.
40
43.4
N.A.
55.4
Protein Similarity:
100
100
99.6
94.3
N.A.
95.9
95.2
N.A.
N.A.
94.1
90.4
90.3
N.A.
64.8
64.4
N.A.
75.1
P-Site Identity:
100
100
93.3
93.3
N.A.
100
93.3
N.A.
N.A.
60
46.6
40
N.A.
33.3
40
N.A.
33.3
P-Site Similarity:
100
100
100
93.3
N.A.
100
93.3
N.A.
N.A.
73.3
73.3
66.6
N.A.
66.6
60
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
30.3
26.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.5
48.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
93
8
15
43
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
8
0
58
15
0
8
% D
% Glu:
0
0
8
0
0
0
100
0
0
65
0
15
15
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
8
0
0
0
0
0
0
0
8
0
8
0
50
8
50
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
8
0
0
15
0
0
0
8
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
8
72
0
22
15
0
% K
% Leu:
0
15
22
0
86
36
0
0
0
8
0
0
0
8
0
% L
% Met:
0
8
43
0
0
65
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
22
0
8
0
8
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
43
0
0
0
0
8
22
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
8
0
0
15
0
0
0
0
% R
% Ser:
0
0
0
58
0
0
0
65
8
8
8
8
0
50
15
% S
% Thr:
0
50
15
0
0
0
0
0
8
0
0
8
0
15
0
% T
% Val:
0
15
0
0
0
0
0
8
22
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _