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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC45L
All Species:
37.88
Human Site:
S516
Identified Species:
64.1
UniProt:
O75419
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75419
NP_003495.1
566
65569
S516
I
P
P
E
T
D
S
S
D
R
K
N
F
F
G
Chimpanzee
Pan troglodytes
XP_514980
566
65532
S516
I
P
P
E
T
D
S
S
D
R
K
N
F
F
G
Rhesus Macaque
Macaca mulatta
XP_001104872
566
65509
S516
I
P
P
E
T
D
S
S
D
R
K
N
F
F
G
Dog
Lupus familis
XP_543547
586
67352
S536
I
P
P
E
T
D
S
S
D
R
K
N
F
F
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z1X9
566
65366
S516
I
P
P
E
T
D
S
S
D
R
K
N
F
F
G
Rat
Rattus norvegicus
NP_001099336
570
65921
S520
I
P
P
E
T
D
S
S
D
R
K
N
F
F
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_415070
566
65691
S516
I
P
P
E
T
E
S
S
D
K
K
N
F
F
G
Frog
Xenopus laevis
Q9YHZ6
567
65426
S517
I
P
P
E
A
E
S
S
D
K
K
N
F
F
G
Zebra Danio
Brachydanio rerio
NP_998551
572
65871
S522
I
P
P
E
S
E
T
S
D
K
K
N
F
F
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569880
575
65872
P527
V
P
V
R
E
D
S
P
R
N
F
F
G
K
A
Honey Bee
Apis mellifera
XP_393560
561
64352
Q512
I
P
P
V
C
E
D
Q
P
R
S
L
F
G
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001180929
568
65050
E517
V
P
P
L
P
E
L
E
Q
S
S
R
N
F
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_189146
596
67533
A547
C
G
K
P
R
L
G
A
V
R
G
N
A
F
G
Baker's Yeast
Sacchar. cerevisiae
Q08032
650
74231
T576
L
A
S
I
D
E
N
T
D
T
Y
L
V
A
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.2
90.2
N.A.
91.6
91
N.A.
N.A.
83.2
78.3
74.3
N.A.
40
43.4
N.A.
55.4
Protein Similarity:
100
100
99.6
94.3
N.A.
95.9
95.2
N.A.
N.A.
94.1
90.4
90.3
N.A.
64.8
64.4
N.A.
75.1
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
86.6
80
73.3
N.A.
20
33.3
N.A.
20
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
93.3
100
N.A.
26.6
40
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
30.3
26.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.5
48.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
0
0
8
0
0
0
0
8
8
8
% A
% Cys:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
50
8
0
72
0
0
0
0
0
0
% D
% Glu:
0
0
0
65
8
43
0
8
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
8
72
79
8
% F
% Gly:
0
8
0
0
0
0
8
0
0
0
8
0
8
8
79
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
72
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
8
0
0
0
0
0
0
22
65
0
0
8
0
% K
% Leu:
8
0
0
8
0
8
8
0
0
0
0
15
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
8
0
72
8
0
0
% N
% Pro:
0
86
79
8
8
0
0
8
8
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% Q
% Arg:
0
0
0
8
8
0
0
0
8
58
0
8
0
0
8
% R
% Ser:
0
0
8
0
8
0
65
65
0
8
15
0
0
0
0
% S
% Thr:
0
0
0
0
50
0
8
8
0
8
0
0
0
0
0
% T
% Val:
15
0
8
8
0
0
0
0
8
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _