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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTX2
All Species:
28.18
Human Site:
S194
Identified Species:
51.67
UniProt:
O75431
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75431
NP_006545.1
263
29763
S194
D
Q
C
C
Q
A
L
S
Q
R
L
G
T
Q
P
Chimpanzee
Pan troglodytes
XP_001153838
253
28805
S184
D
Q
C
C
Q
A
L
S
Q
R
L
G
T
Q
P
Rhesus Macaque
Macaca mulatta
XP_001095310
263
29673
S194
D
Q
C
C
Q
A
L
S
Q
R
L
G
T
Q
P
Dog
Lupus familis
XP_535974
267
30347
S194
D
Q
C
C
Q
A
L
S
Q
R
L
G
T
Q
P
Cat
Felis silvestris
Mouse
Mus musculus
O88441
263
29740
S194
D
Q
C
C
Q
A
L
S
Q
R
L
G
T
Q
P
Rat
Rattus norvegicus
NP_001008287
263
29700
S194
D
R
C
C
Q
A
L
S
Q
R
L
G
T
Q
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515208
248
28473
N180
G
T
Q
P
Y
F
F
N
K
Q
P
T
E
L
D
Chicken
Gallus gallus
XP_421989
276
31162
S194
D
Q
C
C
Q
A
L
S
Q
R
L
G
T
Q
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
NP_001098699
259
29233
C190
Y
E
D
V
N
Q
C
C
Q
A
L
S
Q
R
L
Fruit Fly
Dros. melanogaster
NP_649161
269
31058
E199
A
K
C
C
E
T
L
E
Y
K
L
K
E
S
P
Honey Bee
Apis mellifera
XP_001122107
264
30139
T195
E
E
V
K
N
C
C
T
A
L
S
E
R
L
E
Nematode Worm
Caenorhab. elegans
P34599
230
26066
P162
W
P
L
S
S
V
L
P
F
V
K
R
R
K
I
Sea Urchin
Strong. purpuratus
XP_797071
268
30694
C197
Y
D
E
V
N
L
C
C
K
A
L
S
D
K
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.8
99.6
93.2
N.A.
96.9
93.9
N.A.
76.4
84
N.A.
N.A.
78.7
42
50.3
32.7
47.7
Protein Similarity:
100
96.1
99.6
93.6
N.A.
98.4
96.5
N.A.
84
89.8
N.A.
N.A.
89.7
63.2
68.1
52
62.3
P-Site Identity:
100
100
100
100
N.A.
100
93.3
N.A.
0
100
N.A.
N.A.
13.3
33.3
0
6.6
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
100
N.A.
N.A.
26.6
53.3
20
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
54
0
0
8
16
0
0
0
0
0
% A
% Cys:
0
0
62
62
0
8
24
16
0
0
0
0
0
0
0
% C
% Asp:
54
8
8
0
0
0
0
0
0
0
0
0
8
0
8
% D
% Glu:
8
16
8
0
8
0
0
8
0
0
0
8
16
0
8
% E
% Phe:
0
0
0
0
0
8
8
0
8
0
0
0
0
0
0
% F
% Gly:
8
0
0
0
0
0
0
0
0
0
0
54
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% I
% Lys:
0
8
0
8
0
0
0
0
16
8
8
8
0
16
0
% K
% Leu:
0
0
8
0
0
8
70
0
0
8
77
0
0
16
16
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
24
0
0
8
0
0
0
0
0
0
0
% N
% Pro:
0
8
0
8
0
0
0
8
0
0
8
0
0
0
62
% P
% Gln:
0
47
8
0
54
8
0
0
62
8
0
0
8
54
0
% Q
% Arg:
0
8
0
0
0
0
0
0
0
54
0
8
16
8
0
% R
% Ser:
0
0
0
8
8
0
0
54
0
0
8
16
0
8
0
% S
% Thr:
0
8
0
0
0
8
0
8
0
0
0
8
54
0
0
% T
% Val:
0
0
8
16
0
8
0
0
0
8
0
0
0
0
0
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
16
0
0
0
8
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _