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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTX2
All Species:
27.88
Human Site:
T228
Identified Species:
51.11
UniProt:
O75431
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75431
NP_006545.1
263
29763
T228
T
I
L
T
T
Q
L
T
N
D
E
L
S
E
K
Chimpanzee
Pan troglodytes
XP_001153838
253
28805
T218
T
I
L
T
T
Q
L
T
N
D
E
L
S
E
K
Rhesus Macaque
Macaca mulatta
XP_001095310
263
29673
T228
T
I
L
T
T
Q
L
T
N
D
E
L
S
E
K
Dog
Lupus familis
XP_535974
267
30347
T228
T
I
L
T
T
Q
L
T
N
D
E
L
S
E
K
Cat
Felis silvestris
Mouse
Mus musculus
O88441
263
29740
T228
T
I
L
T
T
Q
L
T
S
D
E
L
S
E
K
Rat
Rattus norvegicus
NP_001008287
263
29700
T228
T
I
L
T
T
Q
L
T
S
D
E
L
C
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515208
248
28473
Y214
F
S
E
K
V
K
N
Y
G
N
L
L
A
F
C
Chicken
Gallus gallus
XP_421989
276
31162
I228
T
I
L
T
T
Q
L
I
T
D
E
L
S
E
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
NP_001098699
259
29233
T224
G
H
L
F
T
I
L
T
T
R
L
T
S
T
E
Fruit Fly
Dros. melanogaster
NP_649161
269
31058
T233
H
L
F
S
I
L
T
T
T
L
P
N
M
A
L
Honey Bee
Apis mellifera
XP_001122107
264
30139
T229
G
H
I
F
T
I
I
T
T
P
L
P
G
N
K
Nematode Worm
Caenorhab. elegans
P34599
230
26066
A196
Q
A
D
K
V
F
R
A
L
S
A
Q
L
G
S
Sea Urchin
Strong. purpuratus
XP_797071
268
30694
M231
G
H
L
K
T
L
Q
M
M
E
A
E
D
K
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.8
99.6
93.2
N.A.
96.9
93.9
N.A.
76.4
84
N.A.
N.A.
78.7
42
50.3
32.7
47.7
Protein Similarity:
100
96.1
99.6
93.6
N.A.
98.4
96.5
N.A.
84
89.8
N.A.
N.A.
89.7
63.2
68.1
52
62.3
P-Site Identity:
100
100
100
100
N.A.
93.3
86.6
N.A.
6.6
86.6
N.A.
N.A.
33.3
6.6
20
0
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
93.3
N.A.
26.6
86.6
N.A.
N.A.
40
20
33.3
0
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
0
8
0
0
16
0
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% C
% Asp:
0
0
8
0
0
0
0
0
0
54
0
0
8
0
0
% D
% Glu:
0
0
8
0
0
0
0
0
0
8
54
8
0
54
8
% E
% Phe:
8
0
8
16
0
8
0
0
0
0
0
0
0
8
0
% F
% Gly:
24
0
0
0
0
0
0
0
8
0
0
0
8
8
0
% G
% His:
8
24
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
54
8
0
8
16
8
8
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
24
0
8
0
0
0
0
0
0
0
8
62
% K
% Leu:
0
8
70
0
0
16
62
0
8
8
24
62
8
0
8
% L
% Met:
0
0
0
0
0
0
0
8
8
0
0
0
8
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
31
8
0
8
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
8
8
0
0
0
% P
% Gln:
8
0
0
0
0
54
8
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
8
% R
% Ser:
0
8
0
8
0
0
0
0
16
8
0
0
54
0
8
% S
% Thr:
54
0
0
54
77
0
8
70
31
0
0
8
0
8
0
% T
% Val:
0
0
0
0
16
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _