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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTX2
All Species:
30.91
Human Site:
Y149
Identified Species:
56.67
UniProt:
O75431
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75431
NP_006545.1
263
29763
Y149
H
A
R
Y
G
S
P
Y
P
W
P
L
N
H
I
Chimpanzee
Pan troglodytes
XP_001153838
253
28805
L143
G
S
P
Y
P
W
P
L
N
H
I
L
A
Y
Q
Rhesus Macaque
Macaca mulatta
XP_001095310
263
29673
Y149
H
A
R
Y
G
S
P
Y
P
W
P
L
N
H
I
Dog
Lupus familis
XP_535974
267
30347
Y149
H
A
R
Y
G
S
P
Y
P
W
P
L
N
H
I
Cat
Felis silvestris
Mouse
Mus musculus
O88441
263
29740
Y149
I
A
R
Y
G
S
P
Y
P
W
P
L
N
H
I
Rat
Rattus norvegicus
NP_001008287
263
29700
Y149
L
A
R
Y
G
S
P
Y
P
W
P
L
N
L
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515208
248
28473
V140
A
Y
Q
K
Q
W
E
V
K
R
K
M
K
A
I
Chicken
Gallus gallus
XP_421989
276
31162
Y149
H
P
R
Y
G
S
P
Y
P
W
P
L
N
R
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
NP_001098699
259
29233
Y149
R
P
R
Y
S
S
P
Y
S
W
P
L
S
S
F
Fruit Fly
Dros. melanogaster
NP_649161
269
31058
F154
A
P
R
N
G
V
V
F
P
W
P
L
N
H
M
Honey Bee
Apis mellifera
XP_001122107
264
30139
Y153
K
V
R
H
G
S
V
Y
P
W
P
L
N
H
F
Nematode Worm
Caenorhab. elegans
P34599
230
26066
I122
M
R
A
N
I
S
M
I
E
H
L
L
T
T
V
Sea Urchin
Strong. purpuratus
XP_797071
268
30694
Y155
K
Q
R
Y
G
S
P
Y
P
W
P
L
S
L
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.8
99.6
93.2
N.A.
96.9
93.9
N.A.
76.4
84
N.A.
N.A.
78.7
42
50.3
32.7
47.7
Protein Similarity:
100
96.1
99.6
93.6
N.A.
98.4
96.5
N.A.
84
89.8
N.A.
N.A.
89.7
63.2
68.1
52
62.3
P-Site Identity:
100
20
100
100
N.A.
93.3
86.6
N.A.
6.6
86.6
N.A.
N.A.
53.3
53.3
66.6
13.3
73.3
P-Site Similarity:
100
33.3
100
100
N.A.
93.3
86.6
N.A.
20
86.6
N.A.
N.A.
60
66.6
73.3
20
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
39
8
0
0
0
0
0
0
0
0
0
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
8
0
8
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
16
% F
% Gly:
8
0
0
0
70
0
0
0
0
0
0
0
0
0
0
% G
% His:
31
0
0
8
0
0
0
0
0
16
0
0
0
47
0
% H
% Ile:
8
0
0
0
8
0
0
8
0
0
8
0
0
0
62
% I
% Lys:
16
0
0
8
0
0
0
0
8
0
8
0
8
0
0
% K
% Leu:
8
0
0
0
0
0
0
8
0
0
8
93
0
16
0
% L
% Met:
8
0
0
0
0
0
8
0
0
0
0
8
0
0
8
% M
% Asn:
0
0
0
16
0
0
0
0
8
0
0
0
62
0
0
% N
% Pro:
0
24
8
0
8
0
70
0
70
0
77
0
0
0
0
% P
% Gln:
0
8
8
0
8
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
8
8
77
0
0
0
0
0
0
8
0
0
0
8
0
% R
% Ser:
0
8
0
0
8
77
0
0
8
0
0
0
16
8
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% T
% Val:
0
8
0
0
0
8
16
8
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
16
0
0
0
77
0
0
0
0
0
% W
% Tyr:
0
8
0
70
0
0
0
70
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _