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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTX2
All Species:
30.61
Human Site:
Y159
Identified Species:
56.11
UniProt:
O75431
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75431
NP_006545.1
263
29763
Y159
P
L
N
H
I
L
A
Y
Q
K
Q
W
E
V
K
Chimpanzee
Pan troglodytes
XP_001153838
253
28805
W153
I
L
A
Y
Q
K
Q
W
E
V
K
R
K
M
K
Rhesus Macaque
Macaca mulatta
XP_001095310
263
29673
Y159
P
L
N
H
I
L
A
Y
Q
K
Q
W
E
V
K
Dog
Lupus familis
XP_535974
267
30347
Y159
P
L
N
H
I
L
A
Y
Q
K
Q
W
E
V
K
Cat
Felis silvestris
Mouse
Mus musculus
O88441
263
29740
Y159
P
L
N
H
I
L
A
Y
Q
K
Q
W
E
V
K
Rat
Rattus norvegicus
NP_001008287
263
29700
Y159
P
L
N
L
I
L
T
Y
Q
K
Q
C
E
V
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515208
248
28473
G150
K
M
K
A
I
G
W
G
G
K
T
L
E
Q
V
Chicken
Gallus gallus
XP_421989
276
31162
Y159
P
L
N
R
I
L
S
Y
Q
K
Q
W
E
I
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
NP_001098699
259
29233
Y159
P
L
S
S
F
L
A
Y
Q
K
Q
W
E
V
R
Fruit Fly
Dros. melanogaster
NP_649161
269
31058
Y164
P
L
N
H
M
Q
N
Y
G
K
R
R
N
A
L
Honey Bee
Apis mellifera
XP_001122107
264
30139
W163
P
L
N
H
F
L
N
W
Q
K
R
K
E
V
I
Nematode Worm
Caenorhab. elegans
P34599
230
26066
F132
L
L
T
T
V
E
K
F
V
L
W
N
H
D
E
Sea Urchin
Strong. purpuratus
XP_797071
268
30694
Y165
P
L
S
L
I
L
P
Y
L
K
Q
R
E
A
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.8
99.6
93.2
N.A.
96.9
93.9
N.A.
76.4
84
N.A.
N.A.
78.7
42
50.3
32.7
47.7
Protein Similarity:
100
96.1
99.6
93.6
N.A.
98.4
96.5
N.A.
84
89.8
N.A.
N.A.
89.7
63.2
68.1
52
62.3
P-Site Identity:
100
13.3
100
100
N.A.
100
80
N.A.
20
73.3
N.A.
N.A.
73.3
40
60
6.6
53.3
P-Site Similarity:
100
53.3
100
100
N.A.
100
80
N.A.
26.6
93.3
N.A.
N.A.
86.6
53.3
73.3
26.6
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
0
0
39
0
0
0
0
0
0
16
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% D
% Glu:
0
0
0
0
0
8
0
0
8
0
0
0
77
0
8
% E
% Phe:
0
0
0
0
16
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
8
0
8
16
0
0
0
0
0
0
% G
% His:
0
0
0
47
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
8
0
0
0
62
0
0
0
0
0
0
0
0
8
8
% I
% Lys:
8
0
8
0
0
8
8
0
0
85
8
8
8
0
47
% K
% Leu:
8
93
0
16
0
70
0
0
8
8
0
8
0
0
8
% L
% Met:
0
8
0
0
8
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
62
0
0
0
16
0
0
0
0
8
8
0
0
% N
% Pro:
77
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
8
8
0
62
0
62
0
0
8
0
% Q
% Arg:
0
0
0
8
0
0
0
0
0
0
16
24
0
0
16
% R
% Ser:
0
0
16
8
0
0
8
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
8
8
0
0
8
0
0
0
8
0
0
0
0
% T
% Val:
0
0
0
0
8
0
0
0
8
8
0
0
0
54
16
% V
% Trp:
0
0
0
0
0
0
8
16
0
0
8
47
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
70
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _