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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTX2
All Species:
24.24
Human Site:
Y220
Identified Species:
44.44
UniProt:
O75431
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75431
NP_006545.1
263
29763
Y220
A
L
V
F
G
H
L
Y
T
I
L
T
T
Q
L
Chimpanzee
Pan troglodytes
XP_001153838
253
28805
Y210
A
L
V
F
G
H
L
Y
T
I
L
T
T
Q
L
Rhesus Macaque
Macaca mulatta
XP_001095310
263
29673
Y220
A
L
V
F
G
H
L
Y
T
I
L
T
T
Q
L
Dog
Lupus familis
XP_535974
267
30347
Y220
A
L
V
F
G
H
L
Y
T
I
L
T
T
Q
L
Cat
Felis silvestris
Mouse
Mus musculus
O88441
263
29740
Y220
A
L
V
F
G
H
L
Y
T
I
L
T
T
Q
L
Rat
Rattus norvegicus
NP_001008287
263
29700
Y220
A
L
V
F
G
H
L
Y
T
I
L
T
T
Q
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515208
248
28473
A206
T
T
Q
L
T
T
D
A
F
S
E
K
V
K
N
Chicken
Gallus gallus
XP_421989
276
31162
F220
A
L
V
F
G
H
L
F
T
I
L
T
T
Q
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
NP_001098699
259
29233
F216
T
E
L
D
A
L
V
F
G
H
L
F
T
I
L
Fruit Fly
Dros. melanogaster
NP_649161
269
31058
G225
E
L
D
A
I
A
F
G
H
L
F
S
I
L
T
Honey Bee
Apis mellifera
XP_001122107
264
30139
F221
N
E
L
D
A
L
V
F
G
H
I
F
T
I
I
Nematode Worm
Caenorhab. elegans
P34599
230
26066
E188
K
T
M
D
E
V
G
E
Q
A
D
K
V
F
R
Sea Urchin
Strong. purpuratus
XP_797071
268
30694
Y223
T
E
L
D
A
L
V
Y
G
H
L
K
T
L
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.8
99.6
93.2
N.A.
96.9
93.9
N.A.
76.4
84
N.A.
N.A.
78.7
42
50.3
32.7
47.7
Protein Similarity:
100
96.1
99.6
93.6
N.A.
98.4
96.5
N.A.
84
89.8
N.A.
N.A.
89.7
63.2
68.1
52
62.3
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
93.3
N.A.
N.A.
20
6.6
6.6
0
20
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
6.6
100
N.A.
N.A.
40
20
40
6.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
54
0
0
8
24
8
0
8
0
8
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
31
0
0
8
0
0
0
8
0
0
0
0
% D
% Glu:
8
24
0
0
8
0
0
8
0
0
8
0
0
0
0
% E
% Phe:
0
0
0
54
0
0
8
24
8
0
8
16
0
8
0
% F
% Gly:
0
0
0
0
54
0
8
8
24
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
54
0
0
8
24
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
0
0
0
54
8
0
8
16
8
% I
% Lys:
8
0
0
0
0
0
0
0
0
0
0
24
0
8
0
% K
% Leu:
0
62
24
8
0
24
54
0
0
8
70
0
0
16
62
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
8
0
0
0
0
54
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% R
% Ser:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
0
% S
% Thr:
24
16
0
0
8
8
0
0
54
0
0
54
77
0
8
% T
% Val:
0
0
54
0
0
8
24
0
0
0
0
0
16
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
54
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _