Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PMPCB All Species: 14.24
Human Site: S22 Identified Species: 20.89
UniProt: O75439 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75439 NP_004270.2 489 54366 S22 R R R L W G F S E S L L I R G
Chimpanzee Pan troglodytes XP_001160333 489 54373 S22 R R R L W G F S E S F L I R G
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533104 513 56776 P46 A G R A S R P P R V W V P P A
Cat Felis silvestris
Mouse Mus musculus Q9CXT8 489 54596 T22 R R R L W G F T R R L P L R R
Rat Rattus norvegicus Q03346 489 54247 T22 G R R L W G F T R R L P L R A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507859 495 54657 S28 G R R P L W R S A E A F V G G
Chicken Gallus gallus XP_415962 487 54047 A19 R L F L P W C A R L A R P S G
Frog Xenopus laevis NP_001085137 479 53355 V21 K A A I R G L V S K S Q P I G
Zebra Danio Brachydanio rerio NP_001012514 470 52313 L19 G R H L I K N L F N T K V I N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650401 470 51856 V19 M R S F M R G V D M I K R Y K
Honey Bee Apis mellifera XP_393509 477 53330 N19 L R A Y S N K N S L V K I Q K
Nematode Worm Caenorhab. elegans P98080 471 51717 S24 S Q V R N A S S A V S V K D V
Sea Urchin Strong. purpuratus XP_001176813 476 53032 S19 L S R F A T K S H A G R N A G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q42290 531 59141 K62 D H A A E I I K N K I K K L E
Baker's Yeast Sacchar. cerevisiae P10507 462 51065 I19 T R R L L S T I S S Q I P G T
Red Bread Mold Neurospora crassa P11913 476 52538 R27 G V I N P F R R G L A T P H S
Conservation
Percent
Protein Identity: 100 99.3 N.A. 87.5 N.A. 90.1 89.7 N.A. 82.8 81.8 82.6 77.9 N.A. 66 62.5 38 70.7
Protein Similarity: 100 99.3 N.A. 91.2 N.A. 94.8 95 N.A. 90 89.7 88.9 85 N.A. 76.2 77.5 59.9 84.2
P-Site Identity: 100 93.3 N.A. 6.6 N.A. 60 53.3 N.A. 26.6 20 13.3 13.3 N.A. 6.6 13.3 6.6 20
P-Site Similarity: 100 93.3 N.A. 13.3 N.A. 73.3 66.6 N.A. 33.3 26.6 26.6 26.6 N.A. 20 33.3 20 26.6
Percent
Protein Identity: N.A. N.A. N.A. 46.1 43.3 48.2
Protein Similarity: N.A. N.A. N.A. 63.8 61.9 66.6
P-Site Identity: N.A. N.A. N.A. 0 26.6 0
P-Site Similarity: N.A. N.A. N.A. 6.6 33.3 0
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 19 13 7 7 0 7 13 7 19 0 0 7 13 % A
% Cys: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 0 0 0 0 0 0 7 0 0 0 0 7 0 % D
% Glu: 0 0 0 0 7 0 0 0 13 7 0 0 0 0 7 % E
% Phe: 0 0 7 13 0 7 25 0 7 0 7 7 0 0 0 % F
% Gly: 25 7 0 0 0 32 7 0 7 0 7 0 0 13 38 % G
% His: 0 7 7 0 0 0 0 0 7 0 0 0 0 7 0 % H
% Ile: 0 0 7 7 7 7 7 7 0 0 13 7 19 13 0 % I
% Lys: 7 0 0 0 0 7 13 7 0 13 0 25 13 0 13 % K
% Leu: 13 7 0 44 13 0 7 7 0 19 19 13 13 7 0 % L
% Met: 7 0 0 0 7 0 0 0 0 7 0 0 0 0 0 % M
% Asn: 0 0 0 7 7 7 7 7 7 7 0 0 7 0 7 % N
% Pro: 0 0 0 7 13 0 7 7 0 0 0 13 32 7 0 % P
% Gln: 0 7 0 0 0 0 0 0 0 0 7 7 0 7 0 % Q
% Arg: 25 57 50 7 7 13 13 7 25 13 0 13 7 25 7 % R
% Ser: 7 7 7 0 13 7 7 32 19 19 13 0 0 7 7 % S
% Thr: 7 0 0 0 0 7 7 13 0 0 7 7 0 0 7 % T
% Val: 0 7 7 0 0 0 0 13 0 13 7 13 13 0 7 % V
% Trp: 0 0 0 0 25 13 0 0 0 0 7 0 0 0 0 % W
% Tyr: 0 0 0 7 0 0 0 0 0 0 0 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _