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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PMPCB
All Species:
49.09
Human Site:
S220
Identified Species:
72
UniProt:
O75439
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75439
NP_004270.2
489
54366
S220
G
P
T
E
N
I
K
S
I
S
R
K
D
L
V
Chimpanzee
Pan troglodytes
XP_001160333
489
54373
S220
G
P
T
E
N
I
K
S
I
S
R
K
D
L
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_533104
513
56776
S244
G
P
T
E
N
I
K
S
I
N
R
K
D
L
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9CXT8
489
54596
S220
G
P
T
E
N
I
K
S
I
N
R
K
D
L
V
Rat
Rattus norvegicus
Q03346
489
54247
S220
G
P
T
E
N
I
K
S
I
S
R
K
D
L
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507859
495
54657
S226
G
P
T
E
N
I
K
S
I
N
R
N
D
L
V
Chicken
Gallus gallus
XP_415962
487
54047
S217
G
P
T
E
N
I
K
S
I
N
R
N
D
L
V
Frog
Xenopus laevis
NP_001085137
479
53355
S212
G
P
T
E
N
I
K
S
I
N
R
N
D
L
V
Zebra Danio
Brachydanio rerio
NP_001012514
470
52313
T206
G
P
T
E
N
I
K
T
I
N
R
G
D
L
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650401
470
51856
I213
K
A
D
L
T
D
Y
I
Q
T
H
Y
K
A
S
Honey Bee
Apis mellifera
XP_393509
477
53330
S207
G
P
T
K
N
I
K
S
I
T
R
N
D
L
L
Nematode Worm
Caenorhab. elegans
P98080
471
51717
E211
Q
Q
L
K
E
W
Q
E
D
H
Y
R
P
V
R
Sea Urchin
Strong. purpuratus
XP_001176813
476
53032
S207
G
P
T
E
N
I
R
S
I
N
R
D
D
L
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q42290
531
59141
S260
G
P
A
Q
N
V
K
S
I
T
R
E
D
L
Q
Baker's Yeast
Sacchar. cerevisiae
P10507
462
51065
G205
Y
I
T
K
N
Y
K
G
D
R
M
V
L
A
G
Red Bread Mold
Neurospora crassa
P11913
476
52538
T218
N
Y
I
K
N
N
Y
T
A
D
R
M
V
L
V
Conservation
Percent
Protein Identity:
100
99.3
N.A.
87.5
N.A.
90.1
89.7
N.A.
82.8
81.8
82.6
77.9
N.A.
66
62.5
38
70.7
Protein Similarity:
100
99.3
N.A.
91.2
N.A.
94.8
95
N.A.
90
89.7
88.9
85
N.A.
76.2
77.5
59.9
84.2
P-Site Identity:
100
100
N.A.
93.3
N.A.
93.3
100
N.A.
86.6
86.6
86.6
80
N.A.
0
73.3
0
73.3
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
93.3
93.3
93.3
93.3
N.A.
6.6
93.3
26.6
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.1
43.3
48.2
Protein Similarity:
N.A.
N.A.
N.A.
63.8
61.9
66.6
P-Site Identity:
N.A.
N.A.
N.A.
60
20
26.6
P-Site Similarity:
N.A.
N.A.
N.A.
86.6
26.6
40
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
0
0
0
0
0
7
0
0
0
0
13
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
0
0
7
0
0
13
7
0
7
75
0
0
% D
% Glu:
0
0
0
63
7
0
0
7
0
0
0
7
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
75
0
0
0
0
0
0
7
0
0
0
7
0
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
7
7
0
0
0
0
% H
% Ile:
0
7
7
0
0
69
0
7
75
0
0
0
0
0
0
% I
% Lys:
7
0
0
25
0
0
75
0
0
0
0
32
7
0
0
% K
% Leu:
0
0
7
7
0
0
0
0
0
0
0
0
7
82
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
7
7
0
0
0
% M
% Asn:
7
0
0
0
88
7
0
0
0
44
0
25
0
0
0
% N
% Pro:
0
75
0
0
0
0
0
0
0
0
0
0
7
0
0
% P
% Gln:
7
7
0
7
0
0
7
0
7
0
0
0
0
0
13
% Q
% Arg:
0
0
0
0
0
0
7
0
0
7
82
7
0
0
7
% R
% Ser:
0
0
0
0
0
0
0
69
0
19
0
0
0
0
7
% S
% Thr:
0
0
75
0
7
0
0
13
0
19
0
0
0
0
0
% T
% Val:
0
0
0
0
0
7
0
0
0
0
0
7
7
7
63
% V
% Trp:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
7
0
0
0
7
13
0
0
0
7
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _