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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PMPCB All Species: 56.36
Human Site: T406 Identified Species: 82.67
UniProt: O75439 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75439 NP_004270.2 489 54366 T406 R A R N L L K T N M L L Q L D
Chimpanzee Pan troglodytes XP_001160333 489 54373 T406 R A R N L L K T N M L L Q L D
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533104 513 56776 T430 R A K N L L K T N M L L Q L D
Cat Felis silvestris
Mouse Mus musculus Q9CXT8 489 54596 T406 R A K N L L K T N M L L Q L D
Rat Rattus norvegicus Q03346 489 54247 T406 R A K N L L K T N M L L Q L D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507859 495 54657 T412 R A K N L L K T N M L L Q L D
Chicken Gallus gallus XP_415962 487 54047 T404 R A K N L L K T N M L L Q L D
Frog Xenopus laevis NP_001085137 479 53355 T396 R A K N L L K T N M L L Q L D
Zebra Danio Brachydanio rerio NP_001012514 470 52313 T390 R A K N L L K T N M L L H L D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650401 470 51856 T387 R A K N L L K T N M L L Q L D
Honey Bee Apis mellifera XP_393509 477 53330 T394 R A K N I L K T N M L L Q L D
Nematode Worm Caenorhab. elegans P98080 471 51717 T388 M A K N Q F R T N L Y Q N L E
Sea Urchin Strong. purpuratus XP_001176813 476 53032 T393 R A K N L L R T N M L L Q L D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q42290 531 59141 S448 R A R N Q L K S S L L L H M D
Baker's Yeast Sacchar. cerevisiae P10507 462 51065 A382 R A K A Q L K A A L L L S L D
Red Bread Mold Neurospora crassa P11913 476 52538 A393 R A K A Q L K A S I L L S L D
Conservation
Percent
Protein Identity: 100 99.3 N.A. 87.5 N.A. 90.1 89.7 N.A. 82.8 81.8 82.6 77.9 N.A. 66 62.5 38 70.7
Protein Similarity: 100 99.3 N.A. 91.2 N.A. 94.8 95 N.A. 90 89.7 88.9 85 N.A. 76.2 77.5 59.9 84.2
P-Site Identity: 100 100 N.A. 93.3 N.A. 93.3 93.3 N.A. 93.3 93.3 93.3 86.6 N.A. 93.3 86.6 33.3 86.6
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 100 100 93.3 N.A. 100 100 60 100
Percent
Protein Identity: N.A. N.A. N.A. 46.1 43.3 48.2
Protein Similarity: N.A. N.A. N.A. 63.8 61.9 66.6
P-Site Identity: N.A. N.A. N.A. 60 53.3 53.3
P-Site Similarity: N.A. N.A. N.A. 86.6 66.6 73.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 100 0 13 0 0 0 13 7 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 94 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % E
% Phe: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 13 0 0 % H
% Ile: 0 0 0 0 7 0 0 0 0 7 0 0 0 0 0 % I
% Lys: 0 0 82 0 0 0 88 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 69 94 0 0 0 19 94 94 0 94 0 % L
% Met: 7 0 0 0 0 0 0 0 0 75 0 0 0 7 0 % M
% Asn: 0 0 0 88 0 0 0 0 82 0 0 0 7 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 25 0 0 0 0 0 0 7 69 0 0 % Q
% Arg: 94 0 19 0 0 0 13 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 7 13 0 0 0 13 0 0 % S
% Thr: 0 0 0 0 0 0 0 82 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _