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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PMPCB All Species: 43.03
Human Site: Y202 Identified Species: 63.11
UniProt: O75439 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75439 NP_004270.2 489 54366 Y202 D Y L H A T A Y Q N T A L G R
Chimpanzee Pan troglodytes XP_001160333 489 54373 Y202 D Y L H A T A Y Q N T A L G R
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533104 513 56776 Y226 D Y L H A T A Y Q N T A L G R
Cat Felis silvestris
Mouse Mus musculus Q9CXT8 489 54596 Y202 D Y L H A T A Y Q N T A L G R
Rat Rattus norvegicus Q03346 489 54247 Y202 D Y L H A T A Y Q N T A L G R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507859 495 54657 Y208 D Y L H A T A Y Q N T A L G R
Chicken Gallus gallus XP_415962 487 54047 Y199 D Y L H A T A Y Q K T A L G R
Frog Xenopus laevis NP_001085137 479 53355 Y194 D Y L H A T A Y H N T A L G R
Zebra Danio Brachydanio rerio NP_001012514 470 52313 Y188 D Y L H A T A Y Q E T P L G R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650401 470 51856 L195 T P L G Q T I L G P T K N I Q
Honey Bee Apis mellifera XP_393509 477 53330 Y189 D H L H A S A Y Q G T P L G R
Nematode Worm Caenorhab. elegans P98080 471 51717 G193 P L A L S V L G T S E S I P N
Sea Urchin Strong. purpuratus XP_001176813 476 53032 Y189 D H L H A T A Y Q G T P L G R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q42290 531 59141 F242 D H L H A T A F Q Y T P L G R
Baker's Yeast Sacchar. cerevisiae P10507 462 51065 I187 I L G P I K N I K S I T R T D
Red Bread Mold Neurospora crassa P11913 476 52538 N200 T I L G P R E N I R D I T R T
Conservation
Percent
Protein Identity: 100 99.3 N.A. 87.5 N.A. 90.1 89.7 N.A. 82.8 81.8 82.6 77.9 N.A. 66 62.5 38 70.7
Protein Similarity: 100 99.3 N.A. 91.2 N.A. 94.8 95 N.A. 90 89.7 88.9 85 N.A. 76.2 77.5 59.9 84.2
P-Site Identity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 93.3 93.3 86.6 N.A. 20 73.3 0 80
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 93.3 93.3 86.6 N.A. 26.6 86.6 26.6 86.6
Percent
Protein Identity: N.A. N.A. N.A. 46.1 43.3 48.2
Protein Similarity: N.A. N.A. N.A. 63.8 61.9 66.6
P-Site Identity: N.A. N.A. N.A. 73.3 0 6.6
P-Site Similarity: N.A. N.A. N.A. 86.6 13.3 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 75 0 75 0 0 0 0 50 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 75 0 0 0 0 0 0 0 0 0 7 0 0 0 7 % D
% Glu: 0 0 0 0 0 0 7 0 0 7 7 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % F
% Gly: 0 0 7 13 0 0 0 7 7 13 0 0 0 75 0 % G
% His: 0 19 0 75 0 0 0 0 7 0 0 0 0 0 0 % H
% Ile: 7 7 0 0 7 0 7 7 7 0 7 7 7 7 0 % I
% Lys: 0 0 0 0 0 7 0 0 7 7 0 7 0 0 0 % K
% Leu: 0 13 88 7 0 0 7 7 0 0 0 0 75 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 7 7 0 44 0 0 7 0 7 % N
% Pro: 7 7 0 7 7 0 0 0 0 7 0 25 0 7 0 % P
% Gln: 0 0 0 0 7 0 0 0 69 0 0 0 0 0 7 % Q
% Arg: 0 0 0 0 0 7 0 0 0 7 0 0 7 7 75 % R
% Ser: 0 0 0 0 7 7 0 0 0 13 0 7 0 0 0 % S
% Thr: 13 0 0 0 0 75 0 0 7 0 82 7 7 7 7 % T
% Val: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 57 0 0 0 0 0 69 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _