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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PMPCB All Species: 11.21
Human Site: Y36 Identified Species: 16.44
UniProt: O75439 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75439 NP_004270.2 489 54366 Y36 G A A G R S L Y F G E N R L R
Chimpanzee Pan troglodytes XP_001160333 489 54373 Y36 G A A G R S L Y F G E N R L R
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533104 513 56776 C60 A R G L P S L C L G G S R W R
Cat Felis silvestris
Mouse Mus musculus Q9CXT8 489 54596 Y36 R A A A Q P L Y F G G D R L R
Rat Rattus norvegicus Q03346 489 54247 Y36 A A A A Q P L Y F G G D R L R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507859 495 54657 N42 G V G R R P I N V G E K R F R
Chicken Gallus gallus XP_415962 487 54047 H33 G S G N R C V H V G K G R F R
Frog Xenopus laevis NP_001085137 479 53355 R35 G F G I S R N R S T Q A F T Q
Zebra Danio Brachydanio rerio NP_001012514 470 52313 A33 N R S V S A P A V N Q V V L N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650401 470 51856 K33 K S A A T L Q K T L L N I P A
Honey Bee Apis mellifera XP_393509 477 53330 A33 K Q W R S T S A S L K E I L M
Nematode Worm Caenorhab. elegans P98080 471 51717 A38 V L A S A P Q A E V T T L K N
Sea Urchin Strong. purpuratus XP_001176813 476 53032 Q33 G S R L R S T Q T A S E T L V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q42290 531 59141 L76 E N P D K R F L K Y A S P H P
Baker's Yeast Sacchar. cerevisiae P10507 462 51065 N33 T R T S K L P N G L T I A T E
Red Bread Mold Neurospora crassa P11913 476 52538 Q41 S G T G I K T Q T T T L K N G
Conservation
Percent
Protein Identity: 100 99.3 N.A. 87.5 N.A. 90.1 89.7 N.A. 82.8 81.8 82.6 77.9 N.A. 66 62.5 38 70.7
Protein Similarity: 100 99.3 N.A. 91.2 N.A. 94.8 95 N.A. 90 89.7 88.9 85 N.A. 76.2 77.5 59.9 84.2
P-Site Identity: 100 100 N.A. 33.3 N.A. 60 60 N.A. 40 33.3 6.6 6.6 N.A. 13.3 6.6 6.6 26.6
P-Site Similarity: 100 100 N.A. 40 N.A. 73.3 73.3 N.A. 46.6 60 20 26.6 N.A. 20 20 6.6 33.3
Percent
Protein Identity: N.A. N.A. N.A. 46.1 43.3 48.2
Protein Similarity: N.A. N.A. N.A. 63.8 61.9 66.6
P-Site Identity: N.A. N.A. N.A. 0 0 6.6
P-Site Similarity: N.A. N.A. N.A. 13.3 6.6 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 13 25 38 19 7 7 0 19 0 7 7 7 7 0 7 % A
% Cys: 0 0 0 0 0 7 0 7 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 7 0 0 0 0 0 0 0 13 0 0 0 % D
% Glu: 7 0 0 0 0 0 0 0 7 0 19 13 0 0 7 % E
% Phe: 0 7 0 0 0 0 7 0 25 0 0 0 7 13 0 % F
% Gly: 38 7 25 19 0 0 0 0 7 44 19 7 0 0 7 % G
% His: 0 0 0 0 0 0 0 7 0 0 0 0 0 7 0 % H
% Ile: 0 0 0 7 7 0 7 0 0 0 0 7 13 0 0 % I
% Lys: 13 0 0 0 13 7 0 7 7 0 13 7 7 7 0 % K
% Leu: 0 7 0 13 0 13 32 7 7 19 7 7 7 44 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % M
% Asn: 7 7 0 7 0 0 7 13 0 7 0 19 0 7 13 % N
% Pro: 0 0 7 0 7 25 13 0 0 0 0 0 7 7 7 % P
% Gln: 0 7 0 0 13 0 13 13 0 0 13 0 0 0 7 % Q
% Arg: 7 19 7 13 32 13 0 7 0 0 0 0 44 0 44 % R
% Ser: 7 19 7 13 19 25 7 0 13 0 7 13 0 0 0 % S
% Thr: 7 0 13 0 7 7 13 0 19 13 19 7 7 13 0 % T
% Val: 7 7 0 7 0 0 7 0 19 7 0 7 7 0 7 % V
% Trp: 0 0 7 0 0 0 0 0 0 0 0 0 0 7 0 % W
% Tyr: 0 0 0 0 0 0 0 25 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _