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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ERN1 All Species: 16.97
Human Site: S290 Identified Species: 28.72
UniProt: O75460 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75460 NP_001424.3 977 109735 S290 T L Y V G K Y S T S L Y A S P
Chimpanzee Pan troglodytes XP_511585 968 108684 S294 I N L V D Q T S E N A P T T V
Rhesus Macaque Macaca mulatta XP_001109583 1070 119711 S383 T L Y V G K Y S T S L Y A S P
Dog Lupus familis XP_853409 975 109686 S290 T L Y V G K Y S T S L Y A S P
Cat Felis silvestris
Mouse Mus musculus Q9EQY0 977 110166 S292 T L Y V G K Y S T S L Y A S P
Rat Rattus norvegicus XP_573211 965 109012 P287 S T S L Y A S P S M V H E G V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510886 942 106736 E285 G S S F P L L E G P Q T D G V
Chicken Gallus gallus
Frog Xenopus laevis NP_001085649 958 108223 V295 S L Y V G K H V T G F Y A T S
Zebra Danio Brachydanio rerio XP_001919350 921 102695 V284 Q L V P T L Y V G K T E S H L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001097839 1074 120152 Y286 T T V S D E A Y Q A I L E E S
Honey Bee Apis mellifera XP_392044 968 110555 R285 T L N L I L K R F A N K P S D
Nematode Worm Caenorhab. elegans Q09499 967 109804 A298 L T N Q F F P A L F V G E S S
Sea Urchin Strong. purpuratus XP_786178 1112 123199 S310 L Y I G D Y P S G L L A L P A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32361 1115 126957 H290 T I F E L G I H S Y D G A S Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.7 90.3 95.5 N.A. 93.1 92.1 N.A. 83 N.A. 56 57 N.A. 37.7 43 41.3 41.4
Protein Similarity: 100 84.8 91 97.3 N.A. 96.3 94.8 N.A. 89.3 N.A. 71.4 69.8 N.A. 52.9 58.6 59.3 54.4
P-Site Identity: 100 13.3 100 100 N.A. 100 0 N.A. 0 N.A. 53.3 13.3 N.A. 6.6 20 6.6 13.3
P-Site Similarity: 100 33.3 100 100 N.A. 100 33.3 N.A. 0 N.A. 73.3 20 N.A. 26.6 33.3 20 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 25.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 8 8 8 0 15 8 8 43 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 22 0 0 0 0 0 8 0 8 0 8 % D
% Glu: 0 0 0 8 0 8 0 8 8 0 0 8 22 8 0 % E
% Phe: 0 0 8 8 8 8 0 0 8 8 8 0 0 0 0 % F
% Gly: 8 0 0 8 36 8 0 0 22 8 0 15 0 15 0 % G
% His: 0 0 0 0 0 0 8 8 0 0 0 8 0 8 0 % H
% Ile: 8 8 8 0 8 0 8 0 0 0 8 0 0 0 0 % I
% Lys: 0 0 0 0 0 36 8 0 0 8 0 8 0 0 0 % K
% Leu: 15 50 8 15 8 22 8 0 8 8 36 8 8 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 8 15 0 0 0 0 0 0 8 8 0 0 0 0 % N
% Pro: 0 0 0 8 8 0 15 8 0 8 0 8 8 8 29 % P
% Gln: 8 0 0 8 0 8 0 0 8 0 8 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % R
% Ser: 15 8 15 8 0 0 8 43 15 29 0 0 8 50 22 % S
% Thr: 50 22 0 0 8 0 8 0 36 0 8 8 8 15 0 % T
% Val: 0 0 15 43 0 0 0 15 0 0 15 0 0 0 22 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 36 0 8 8 36 8 0 8 0 36 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _