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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ERN1 All Species: 13.64
Human Site: S539 Identified Species: 23.08
UniProt: O75460 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75460 NP_001424.3 977 109735 S539 A S N H S L C S G S S A S K A
Chimpanzee Pan troglodytes XP_511585 968 108684 R528 N R D V A V K R I L P E C F S
Rhesus Macaque Macaca mulatta XP_001109583 1070 119711 S632 A S N H S L C S G S S A S K A
Dog Lupus familis XP_853409 975 109686 S537 A S N H S L H S S G S A S K A
Cat Felis silvestris
Mouse Mus musculus Q9EQY0 977 110166 P539 A S N H S L H P S S S A S R A
Rat Rattus norvegicus XP_573211 965 109012 S527 A S N H S L N S S S S A S K A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510886 942 106736 A500 S P N V S P R A S N H S L H S
Chicken Gallus gallus
Frog Xenopus laevis NP_001085649 958 108223 D530 S R S S G K L D E V Q A N G T
Zebra Danio Brachydanio rerio XP_001919350 921 102695 F500 A S N Q T Q P F S S K D S A S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001097839 1074 120152 G516 T F A I A Q N G S N G S T G S
Honey Bee Apis mellifera XP_392044 968 110555 E504 V V P E D M G E G V V K V G K
Nematode Worm Caenorhab. elegans Q09499 967 109804 S514 E G W M A V G S K L M Y S P S
Sea Urchin Strong. purpuratus XP_786178 1112 123199 G481 S E S S Q H S G T G S T G G K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32361 1115 126957 K642 S L D L T T E K K K R K R G S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.7 90.3 95.5 N.A. 93.1 92.1 N.A. 83 N.A. 56 57 N.A. 37.7 43 41.3 41.4
Protein Similarity: 100 84.8 91 97.3 N.A. 96.3 94.8 N.A. 89.3 N.A. 71.4 69.8 N.A. 52.9 58.6 59.3 54.4
P-Site Identity: 100 0 100 80 N.A. 73.3 86.6 N.A. 13.3 N.A. 6.6 33.3 N.A. 0 6.6 13.3 6.6
P-Site Similarity: 100 26.6 100 80 N.A. 80 86.6 N.A. 46.6 N.A. 26.6 46.6 N.A. 33.3 13.3 33.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 25.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 43 0 8 0 22 0 0 8 0 0 0 43 0 8 36 % A
% Cys: 0 0 0 0 0 0 15 0 0 0 0 0 8 0 0 % C
% Asp: 0 0 15 0 8 0 0 8 0 0 0 8 0 0 0 % D
% Glu: 8 8 0 8 0 0 8 8 8 0 0 8 0 0 0 % E
% Phe: 0 8 0 0 0 0 0 8 0 0 0 0 0 8 0 % F
% Gly: 0 8 0 0 8 0 15 15 22 15 8 0 8 36 0 % G
% His: 0 0 0 36 0 8 15 0 0 0 8 0 0 8 0 % H
% Ile: 0 0 0 8 0 0 0 0 8 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 8 8 8 15 8 8 15 0 29 15 % K
% Leu: 0 8 0 8 0 36 8 0 0 15 0 0 8 0 0 % L
% Met: 0 0 0 8 0 8 0 0 0 0 8 0 0 0 0 % M
% Asn: 8 0 50 0 0 0 15 0 0 15 0 0 8 0 0 % N
% Pro: 0 8 8 0 0 8 8 8 0 0 8 0 0 8 0 % P
% Gln: 0 0 0 8 8 15 0 0 0 0 8 0 0 0 0 % Q
% Arg: 0 15 0 0 0 0 8 8 0 0 8 0 8 8 0 % R
% Ser: 29 43 15 15 43 0 8 36 43 36 43 15 50 0 43 % S
% Thr: 8 0 0 0 15 8 0 0 8 0 0 8 8 0 8 % T
% Val: 8 8 0 15 0 15 0 0 0 15 8 0 8 0 0 % V
% Trp: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _