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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ERN1 All Species: 20
Human Site: T274 Identified Species: 33.85
UniProt: O75460 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75460 NP_001424.3 977 109735 T274 K Y P F P K E T E A K S K L T
Chimpanzee Pan troglodytes XP_511585 968 108684 S278 E N V I P A D S E K K S F E E
Rhesus Macaque Macaca mulatta XP_001109583 1070 119711 T367 K Y P F P K E T E A K S K L T
Dog Lupus familis XP_853409 975 109686 T274 K Y P F P K E T E A K S K L T
Cat Felis silvestris
Mouse Mus musculus Q9EQY0 977 110166 T276 K Y P F P K E T E A K S K L T
Rat Rattus norvegicus XP_573211 965 109012 T271 T E A K S K L T P T L Y V G K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510886 942 106736 H269 Y A S P S M V H E G V A V V P
Chicken Gallus gallus
Frog Xenopus laevis NP_001085649 958 108223 S279 Y Q A V Q Q L S S T K T H L L
Zebra Danio Brachydanio rerio XP_001919350 921 102695 T268 M K W T Y Q F T K E S H S T K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001097839 1074 120152 P270 V A A F L L G P D G L L S V P
Honey Bee Apis mellifera XP_392044 968 110555 V269 R E D G L L T V P F T S V A D
Nematode Worm Caenorhab. elegans Q09499 967 109804 N282 W P T V L G V N A A D P Q T T
Sea Urchin Strong. purpuratus XP_786178 1112 123199 T294 R N Q L L G Y T K H T K L V P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32361 1115 126957 C274 E K I K L Q E C E N M I V I G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.7 90.3 95.5 N.A. 93.1 92.1 N.A. 83 N.A. 56 57 N.A. 37.7 43 41.3 41.4
Protein Similarity: 100 84.8 91 97.3 N.A. 96.3 94.8 N.A. 89.3 N.A. 71.4 69.8 N.A. 52.9 58.6 59.3 54.4
P-Site Identity: 100 26.6 100 100 N.A. 100 13.3 N.A. 6.6 N.A. 13.3 6.6 N.A. 6.6 6.6 13.3 6.6
P-Site Similarity: 100 46.6 100 100 N.A. 100 13.3 N.A. 20 N.A. 33.3 20 N.A. 20 13.3 20 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 25.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 15 22 0 0 8 0 0 8 36 0 8 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 0 0 0 8 0 8 0 8 0 0 0 8 % D
% Glu: 15 15 0 0 0 0 36 0 50 8 0 0 0 8 8 % E
% Phe: 0 0 0 36 0 0 8 0 0 8 0 0 8 0 0 % F
% Gly: 0 0 0 8 0 15 8 0 0 15 0 0 0 8 8 % G
% His: 0 0 0 0 0 0 0 8 0 8 0 8 8 0 0 % H
% Ile: 0 0 8 8 0 0 0 0 0 0 0 8 0 8 0 % I
% Lys: 29 15 0 15 0 36 0 0 15 8 43 8 29 0 15 % K
% Leu: 0 0 0 8 36 15 15 0 0 0 15 8 8 36 8 % L
% Met: 8 0 0 0 0 8 0 0 0 0 8 0 0 0 0 % M
% Asn: 0 15 0 0 0 0 0 8 0 8 0 0 0 0 0 % N
% Pro: 0 8 29 8 36 0 0 8 15 0 0 8 0 0 22 % P
% Gln: 0 8 8 0 8 22 0 0 0 0 0 0 8 0 0 % Q
% Arg: 15 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 8 0 15 0 0 15 8 0 8 43 15 0 0 % S
% Thr: 8 0 8 8 0 0 8 50 0 15 15 8 0 15 36 % T
% Val: 8 0 8 15 0 0 15 8 0 0 8 0 29 22 0 % V
% Trp: 8 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 15 29 0 0 8 0 8 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _