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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ERN1 All Species: 18.79
Human Site: T335 Identified Species: 31.79
UniProt: O75460 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75460 NP_001424.3 977 109735 T335 D K G E C V I T P S T D V K F
Chimpanzee Pan troglodytes XP_511585 968 108684 G339 L S T F L L I G W V A F I I T
Rhesus Macaque Macaca mulatta XP_001109583 1070 119711 T428 D K G E C V I T P S T E L K F
Dog Lupus familis XP_853409 975 109686 T335 D K G E C V I T P S T D L K F
Cat Felis silvestris
Mouse Mus musculus Q9EQY0 977 110166 T337 D K G E C V I T P S T D L K F
Rat Rattus norvegicus XP_573211 965 109012 F332 T P S T D L K F D P G L K G K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510886 942 106736 I330 W R N Y W L L I G H H E T P L
Chicken Gallus gallus
Frog Xenopus laevis NP_001085649 958 108223 T340 E S T K F D V T S N T D V R Y
Zebra Danio Brachydanio rerio XP_001919350 921 102695 P329 V T M G N G R P E C E I T P S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001097839 1074 120152 S331 D K N T P R I S T A P P I K L
Honey Bee Apis mellifera XP_392044 968 110555 L330 S N N I G Q L L L E G P L S V
Nematode Worm Caenorhab. elegans Q09499 967 109804 M343 A P I A L T E M E K E E Y L P
Sea Urchin Strong. purpuratus XP_786178 1112 123199 M355 N D R D K P P M N P L S D G T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32361 1115 126957 L335 P F R D K S L L A S D L D F R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.7 90.3 95.5 N.A. 93.1 92.1 N.A. 83 N.A. 56 57 N.A. 37.7 43 41.3 41.4
Protein Similarity: 100 84.8 91 97.3 N.A. 96.3 94.8 N.A. 89.3 N.A. 71.4 69.8 N.A. 52.9 58.6 59.3 54.4
P-Site Identity: 100 6.6 86.6 93.3 N.A. 93.3 0 N.A. 0 N.A. 26.6 0 N.A. 26.6 0 0 0
P-Site Similarity: 100 20 100 100 N.A. 100 6.6 N.A. 26.6 N.A. 66.6 0 N.A. 46.6 13.3 6.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 25.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 8 0 0 0 0 8 8 8 0 0 0 0 % A
% Cys: 0 0 0 0 29 0 0 0 0 8 0 0 0 0 0 % C
% Asp: 36 8 0 15 8 8 0 0 8 0 8 29 15 0 0 % D
% Glu: 8 0 0 29 0 0 8 0 15 8 15 22 0 0 0 % E
% Phe: 0 8 0 8 8 0 0 8 0 0 0 8 0 8 29 % F
% Gly: 0 0 29 8 8 8 0 8 8 0 15 0 0 15 0 % G
% His: 0 0 0 0 0 0 0 0 0 8 8 0 0 0 0 % H
% Ile: 0 0 8 8 0 0 43 8 0 0 0 8 15 8 0 % I
% Lys: 0 36 0 8 15 0 8 0 0 8 0 0 8 36 8 % K
% Leu: 8 0 0 0 15 22 22 15 8 0 8 15 29 8 15 % L
% Met: 0 0 8 0 0 0 0 15 0 0 0 0 0 0 0 % M
% Asn: 8 8 22 0 8 0 0 0 8 8 0 0 0 0 0 % N
% Pro: 8 15 0 0 8 8 8 8 29 15 8 15 0 15 8 % P
% Gln: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 8 15 0 0 8 8 0 0 0 0 0 0 8 8 % R
% Ser: 8 15 8 0 0 8 0 8 8 36 0 8 0 8 8 % S
% Thr: 8 8 15 15 0 8 0 36 8 0 36 0 15 0 15 % T
% Val: 8 0 0 0 0 29 8 0 0 8 0 0 15 0 8 % V
% Trp: 8 0 0 0 8 0 0 0 8 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 0 0 0 0 0 8 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _