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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
E2F6
All Species:
6.97
Human Site:
S258
Identified Species:
15.33
UniProt:
O75461
Number Species:
10
Phosphosite Substitution
Charge Score:
0.4
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75461
NP_937987.2
281
31844
S258
V
G
T
S
S
S
E
S
T
H
P
E
G
P
E
Chimpanzee
Pan troglodytes
XP_001159434
249
28084
T227
G
T
S
S
S
E
S
T
H
P
E
G
P
E
E
Rhesus Macaque
Macaca mulatta
XP_001088811
281
31712
S258
V
G
T
S
S
S
E
S
T
H
A
E
G
P
E
Dog
Lupus familis
XP_852463
282
31896
N258
A
G
T
S
S
S
K
N
K
H
P
E
P
P
N
Cat
Felis silvestris
Mouse
Mus musculus
O54917
272
30864
D249
H
S
N
G
K
T
N
D
G
I
G
A
S
P
S
Rat
Rattus norvegicus
NP_001094187
272
30777
D249
H
S
N
G
K
T
A
D
G
V
G
A
S
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505549
547
60104
E337
M
E
T
S
P
S
S
E
S
K
S
A
V
H
L
Chicken
Gallus gallus
Q90977
403
43534
L297
F
K
A
P
A
E
E
L
S
P
G
S
S
Q
Q
Frog
Xenopus laevis
NP_001081986
429
46399
S337
Q
D
H
N
G
N
V
S
K
P
K
P
H
T
K
Zebra Danio
Brachydanio rerio
NP_001025315
405
45233
D376
E
S
K
L
T
K
S
D
C
F
V
S
L
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001123287
404
44387
P333
A
G
S
K
N
S
S
P
C
S
S
K
G
D
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.9
98.5
95
N.A.
83.9
85
N.A.
35.4
31.7
31.9
33
N.A.
N.A.
N.A.
N.A.
33.6
Protein Similarity:
100
88.2
98.9
96.8
N.A.
89.6
90
N.A.
43.5
47.3
46.1
46.9
N.A.
N.A.
N.A.
N.A.
50
P-Site Identity:
100
20
93.3
60
N.A.
6.6
6.6
N.A.
20
6.6
6.6
6.6
N.A.
N.A.
N.A.
N.A.
20
P-Site Similarity:
100
33.3
93.3
73.3
N.A.
13.3
13.3
N.A.
33.3
26.6
26.6
13.3
N.A.
N.A.
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
19
0
10
0
10
0
10
0
0
0
10
28
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
19
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
0
0
28
0
0
0
0
0
10
0
% D
% Glu:
10
10
0
0
0
19
28
10
0
0
10
28
0
19
37
% E
% Phe:
10
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% F
% Gly:
10
37
0
19
10
0
0
0
19
0
28
10
28
0
0
% G
% His:
19
0
10
0
0
0
0
0
10
28
0
0
10
10
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% I
% Lys:
0
10
10
10
19
10
10
0
19
10
10
10
0
0
10
% K
% Leu:
0
0
0
10
0
0
0
10
0
0
0
0
10
0
10
% L
% Met:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
19
10
10
10
10
10
0
0
0
0
0
0
10
% N
% Pro:
0
0
0
10
10
0
0
10
0
28
19
10
19
46
10
% P
% Gln:
10
0
0
0
0
0
0
0
0
0
0
0
0
10
10
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
28
19
46
37
46
37
28
19
10
19
19
28
0
19
% S
% Thr:
0
10
37
0
10
19
0
10
19
0
0
0
0
10
0
% T
% Val:
19
0
0
0
0
0
10
0
0
10
10
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _