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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
E2F6
All Species:
22.73
Human Site:
Y185
Identified Species:
50
UniProt:
O75461
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75461
NP_937987.2
281
31844
Y185
E
R
L
A
Y
V
T
Y
Q
D
I
H
S
I
Q
Chimpanzee
Pan troglodytes
XP_001159434
249
28084
H157
Y
V
T
Y
Q
D
I
H
S
I
Q
A
F
H
E
Rhesus Macaque
Macaca mulatta
XP_001088811
281
31712
Y185
E
R
L
A
Y
V
T
Y
Q
D
I
H
S
I
Q
Dog
Lupus familis
XP_852463
282
31896
Y185
E
R
L
A
Y
V
T
Y
Q
D
I
H
S
I
Q
Cat
Felis silvestris
Mouse
Mus musculus
O54917
272
30864
R179
T
D
D
K
E
N
E
R
L
A
Y
V
T
Y
Q
Rat
Rattus norvegicus
NP_001094187
272
30777
R179
T
D
D
K
E
N
E
R
L
A
Y
V
T
Y
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505549
547
60104
Y264
A
K
L
A
Y
V
T
Y
Q
D
I
H
S
I
Q
Chicken
Gallus gallus
Q90977
403
43534
C225
Q
H
A
A
Y
V
T
C
Q
D
L
R
S
I
V
Frog
Xenopus laevis
NP_001081986
429
46399
Y265
Q
R
L
A
Y
V
T
Y
Q
D
I
R
K
I
S
Zebra Danio
Brachydanio rerio
NP_001025315
405
45233
Y303
N
T
S
A
Y
V
T
Y
E
D
I
C
Q
I
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001123287
404
44387
Y259
A
R
Y
A
Y
V
T
Y
H
D
I
R
G
I
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.9
98.5
95
N.A.
83.9
85
N.A.
35.4
31.7
31.9
33
N.A.
N.A.
N.A.
N.A.
33.6
Protein Similarity:
100
88.2
98.9
96.8
N.A.
89.6
90
N.A.
43.5
47.3
46.1
46.9
N.A.
N.A.
N.A.
N.A.
50
P-Site Identity:
100
0
100
100
N.A.
6.6
6.6
N.A.
86.6
53.3
73.3
53.3
N.A.
N.A.
N.A.
N.A.
66.6
P-Site Similarity:
100
13.3
100
100
N.A.
13.3
13.3
N.A.
93.3
66.6
80
60
N.A.
N.A.
N.A.
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
19
0
10
73
0
0
0
0
0
19
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
10
0
0
0
10
0
0
0
% C
% Asp:
0
19
19
0
0
10
0
0
0
73
0
0
0
0
10
% D
% Glu:
28
0
0
0
19
0
19
0
10
0
0
0
0
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% G
% His:
0
10
0
0
0
0
0
10
10
0
0
37
0
10
0
% H
% Ile:
0
0
0
0
0
0
10
0
0
10
64
0
0
73
0
% I
% Lys:
0
10
0
19
0
0
0
0
0
0
0
0
10
0
0
% K
% Leu:
0
0
46
0
0
0
0
0
19
0
10
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
0
19
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
19
0
0
0
10
0
0
0
55
0
10
0
10
0
64
% Q
% Arg:
0
46
0
0
0
0
0
19
0
0
0
28
0
0
0
% R
% Ser:
0
0
10
0
0
0
0
0
10
0
0
0
46
0
10
% S
% Thr:
19
10
10
0
0
0
73
0
0
0
0
0
19
0
0
% T
% Val:
0
10
0
0
0
73
0
0
0
0
0
19
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
10
10
73
0
0
64
0
0
19
0
0
19
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _