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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
E2F6
All Species:
18.18
Human Site:
Y50
Identified Species:
40
UniProt:
O75461
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75461
NP_937987.2
281
31844
Y50
N
L
E
D
N
V
Q
Y
V
S
M
R
K
A
L
Chimpanzee
Pan troglodytes
XP_001159434
249
28084
R29
R
K
A
L
K
V
K
R
P
R
F
D
V
S
L
Rhesus Macaque
Macaca mulatta
XP_001088811
281
31712
Y50
N
L
E
D
N
V
Q
Y
V
S
M
R
K
A
L
Dog
Lupus familis
XP_852463
282
31896
Y50
N
L
E
D
N
V
Q
Y
V
S
M
R
K
A
L
Cat
Felis silvestris
Mouse
Mus musculus
O54917
272
30864
Y50
N
L
E
E
N
V
Q
Y
V
S
M
R
K
A
L
Rat
Rattus norvegicus
NP_001094187
272
30777
Y50
N
L
E
E
N
V
Q
Y
V
S
M
R
K
A
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505549
547
60104
L128
T
V
A
R
P
P
F
L
E
A
S
A
G
T
V
Chicken
Gallus gallus
Q90977
403
43534
I91
A
A
R
G
R
A
R
I
P
G
R
G
A
K
S
Frog
Xenopus laevis
NP_001081986
429
46399
D129
R
A
A
T
H
C
P
D
S
P
K
T
P
K
S
Zebra Danio
Brachydanio rerio
NP_001025315
405
45233
N169
P
T
I
L
P
P
V
N
V
A
D
D
V
F
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001123287
404
44387
K118
R
P
S
A
K
T
K
K
P
R
A
P
T
R
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.9
98.5
95
N.A.
83.9
85
N.A.
35.4
31.7
31.9
33
N.A.
N.A.
N.A.
N.A.
33.6
Protein Similarity:
100
88.2
98.9
96.8
N.A.
89.6
90
N.A.
43.5
47.3
46.1
46.9
N.A.
N.A.
N.A.
N.A.
50
P-Site Identity:
100
13.3
100
100
N.A.
93.3
93.3
N.A.
0
0
0
6.6
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
26.6
100
100
N.A.
100
100
N.A.
20
6.6
6.6
13.3
N.A.
N.A.
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
19
28
10
0
10
0
0
0
19
10
10
10
46
0
% A
% Cys:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
28
0
0
0
10
0
0
10
19
0
0
0
% D
% Glu:
0
0
46
19
0
0
0
0
10
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
10
0
0
10
0
% F
% Gly:
0
0
0
10
0
0
0
0
0
10
0
10
10
0
0
% G
% His:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
0
0
0
10
0
0
0
0
0
0
0
% I
% Lys:
0
10
0
0
19
0
19
10
0
0
10
0
46
19
0
% K
% Leu:
0
46
0
19
0
0
0
10
0
0
0
0
0
0
55
% L
% Met:
0
0
0
0
0
0
0
0
0
0
46
0
0
0
0
% M
% Asn:
46
0
0
0
46
0
0
10
0
0
0
0
0
0
10
% N
% Pro:
10
10
0
0
19
19
10
0
28
10
0
10
10
0
0
% P
% Gln:
0
0
0
0
0
0
46
0
0
0
0
0
0
0
0
% Q
% Arg:
28
0
10
10
10
0
10
10
0
19
10
46
0
10
0
% R
% Ser:
0
0
10
0
0
0
0
0
10
46
10
0
0
10
28
% S
% Thr:
10
10
0
10
0
10
0
0
0
0
0
10
10
10
0
% T
% Val:
0
10
0
0
0
55
10
0
55
0
0
0
19
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
46
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _