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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RPS6KA5
All Species:
22.12
Human Site:
S253
Identified Species:
32.44
UniProt:
O75582
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75582
NP_004746.2
802
89865
S253
Y
E
L
L
T
G
A
S
P
F
T
V
D
G
E
Chimpanzee
Pan troglodytes
XP_001140389
894
100719
S345
Y
E
L
L
T
G
A
S
P
F
T
V
D
G
E
Rhesus Macaque
Macaca mulatta
XP_001088246
1054
117436
S511
Y
E
L
L
T
G
A
S
P
F
T
V
D
G
E
Dog
Lupus familis
XP_547953
806
90703
S260
Y
E
L
L
T
G
A
S
P
F
T
V
D
G
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2B9
773
85721
P259
R
R
I
L
K
C
S
P
P
F
P
L
R
I
G
Rat
Rattus norvegicus
Q63531
735
82865
Q263
L
T
G
S
L
P
F
Q
G
K
D
R
K
E
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506738
716
80894
K246
N
W
E
D
L
A
A
K
K
M
P
A
P
F
K
Chicken
Gallus gallus
Q5F3L1
789
89022
P266
R
R
I
L
K
S
E
P
P
Y
P
Q
E
M
S
Frog
Xenopus laevis
P10665
733
82620
Q263
L
T
G
S
L
P
F
Q
G
K
D
R
K
E
T
Zebra Danio
Brachydanio rerio
Q6PFQ0
740
83378
Q268
L
T
G
T
L
P
F
Q
G
K
D
R
N
E
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3I5
1207
137026
S465
F
E
L
L
T
G
A
S
P
F
A
T
S
D
G
Honey Bee
Apis mellifera
XP_395099
910
102507
S271
Y
E
L
L
T
G
A
S
P
F
T
V
E
G
E
Nematode Worm
Caenorhab. elegans
Q18846
772
87050
A254
P
K
T
M
D
V
D
A
R
D
F
I
G
Q
L
Sea Urchin
Strong. purpuratus
XP_786494
918
102561
V255
D
F
I
N
K
L
L
V
K
D
P
T
K
R
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39030
471
53019
S25
F
Q
K
H
L
S
L
S
I
S
P
P
K
S
V
Baker's Yeast
Sacchar. cerevisiae
P18961
677
76646
V231
M
G
T
M
E
Q
P
V
F
N
K
I
S
T
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88.1
75
93.1
N.A.
62.8
41
N.A.
82.1
89.4
40
40.5
N.A.
28.5
45.7
46.8
53.3
Protein Similarity:
100
88.5
75.1
95.1
N.A.
76.6
57.9
N.A.
86.1
94.6
57.4
57.3
N.A.
40
62.3
63
66.2
P-Site Identity:
100
100
100
100
N.A.
20
0
N.A.
6.6
13.3
0
0
N.A.
60
93.3
0
0
P-Site Similarity:
100
100
100
100
N.A.
40
0
N.A.
13.3
33.3
0
6.6
N.A.
66.6
100
26.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
21.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35
38.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
7
44
7
0
0
7
7
0
0
0
% A
% Cys:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
7
7
0
7
0
0
13
19
0
25
7
0
% D
% Glu:
0
38
7
0
7
0
7
0
0
0
0
0
13
19
32
% E
% Phe:
13
7
0
0
0
0
19
0
7
44
7
0
0
7
7
% F
% Gly:
0
7
19
0
0
38
0
0
19
0
0
0
7
32
13
% G
% His:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
19
0
0
0
0
0
7
0
0
13
0
7
0
% I
% Lys:
0
7
7
0
19
0
0
7
13
19
7
0
25
0
7
% K
% Leu:
19
0
38
50
32
7
13
0
0
0
0
7
0
0
13
% L
% Met:
7
0
0
13
0
0
0
0
0
7
0
0
0
7
0
% M
% Asn:
7
0
0
7
0
0
0
0
0
7
0
0
7
0
0
% N
% Pro:
7
0
0
0
0
19
7
13
50
0
32
7
7
0
0
% P
% Gln:
0
7
0
0
0
7
0
19
0
0
0
7
0
7
0
% Q
% Arg:
13
13
0
0
0
0
0
0
7
0
0
19
7
7
0
% R
% Ser:
0
0
0
13
0
13
7
44
0
7
0
0
13
7
7
% S
% Thr:
0
19
13
7
38
0
0
0
0
0
32
13
0
7
19
% T
% Val:
0
0
0
0
0
7
0
13
0
0
0
32
0
0
7
% V
% Trp:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
32
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _