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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RPS6KA5
All Species:
31.52
Human Site:
S376
Identified Species:
46.22
UniProt:
O75582
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75582
NP_004746.2
802
89865
S376
E
K
L
F
Q
G
Y
S
F
V
A
P
S
I
L
Chimpanzee
Pan troglodytes
XP_001140389
894
100719
S468
E
K
L
F
Q
G
Y
S
F
V
A
P
S
I
L
Rhesus Macaque
Macaca mulatta
XP_001088246
1054
117436
S634
E
K
L
F
Q
G
Y
S
F
V
A
P
S
I
L
Dog
Lupus familis
XP_547953
806
90703
S383
E
R
L
F
Q
G
Y
S
F
V
A
P
S
I
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2B9
773
85721
Y359
D
P
R
I
F
Q
G
Y
S
F
V
A
P
S
I
Rat
Rattus norvegicus
Q63531
735
82865
F338
R
R
E
I
K
P
P
F
K
P
A
V
A
Q
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506738
716
80894
G321
H
M
G
I
E
R
P
G
V
T
T
I
A
R
S
Chicken
Gallus gallus
Q5F3L1
789
89022
S366
E
K
I
F
Q
G
Y
S
F
V
A
P
S
I
L
Frog
Xenopus laevis
P10665
733
82620
F338
R
R
E
M
S
P
P
F
K
P
A
V
T
Q
A
Zebra Danio
Brachydanio rerio
Q6PFQ0
740
83378
P350
F
K
P
A
S
G
K
P
D
D
T
F
C
F
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3I5
1207
137026
T588
I
R
L
F
R
G
Y
T
Y
V
A
P
E
H
L
Honey Bee
Apis mellifera
XP_395099
910
102507
S398
D
K
I
F
R
G
Y
S
Y
V
A
P
S
I
L
Nematode Worm
Caenorhab. elegans
Q18846
772
87050
S342
N
T
L
F
R
G
Y
S
Y
V
S
P
S
V
I
Sea Urchin
Strong. purpuratus
XP_786494
918
102561
Y334
D
A
R
V
F
R
G
Y
S
F
I
A
P
S
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39030
471
53019
D100
R
E
T
E
D
S
V
D
L
V
E
C
V
E
G
Baker's Yeast
Sacchar. cerevisiae
P18961
677
76646
A306
N
L
K
I
D
S
A
A
Q
I
R
L
Y
N
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88.1
75
93.1
N.A.
62.8
41
N.A.
82.1
89.4
40
40.5
N.A.
28.5
45.7
46.8
53.3
Protein Similarity:
100
88.5
75.1
95.1
N.A.
76.6
57.9
N.A.
86.1
94.6
57.4
57.3
N.A.
40
62.3
63
66.2
P-Site Identity:
100
100
100
93.3
N.A.
0
6.6
N.A.
0
93.3
6.6
13.3
N.A.
53.3
73.3
53.3
0
P-Site Similarity:
100
100
100
100
N.A.
13.3
26.6
N.A.
13.3
100
20
13.3
N.A.
80
100
86.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
21.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35
38.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
0
0
7
7
0
0
57
13
13
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
7
7
0
0
% C
% Asp:
19
0
0
0
13
0
0
7
7
7
0
0
0
0
7
% D
% Glu:
32
7
13
7
7
0
0
0
0
0
7
0
7
7
0
% E
% Phe:
7
0
0
50
13
0
0
13
32
13
0
7
0
7
0
% F
% Gly:
0
0
7
0
0
57
13
7
0
0
0
0
0
0
7
% G
% His:
7
0
0
0
0
0
0
0
0
0
0
0
0
7
7
% H
% Ile:
7
0
13
25
0
0
0
0
0
7
7
7
0
38
19
% I
% Lys:
0
38
7
0
7
0
7
0
13
0
0
0
0
0
0
% K
% Leu:
0
7
38
0
0
0
0
0
7
0
0
7
0
0
44
% L
% Met:
0
7
0
7
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
13
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% N
% Pro:
0
7
7
0
0
13
19
7
0
13
0
50
13
0
7
% P
% Gln:
0
0
0
0
32
7
0
0
7
0
0
0
0
13
0
% Q
% Arg:
19
25
13
0
19
13
0
0
0
0
7
0
0
7
0
% R
% Ser:
0
0
0
0
13
13
0
44
13
0
7
0
44
13
7
% S
% Thr:
0
7
7
0
0
0
0
7
0
7
13
0
7
0
0
% T
% Val:
0
0
0
7
0
0
7
0
7
57
7
13
7
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
50
13
19
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _