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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RPS6KA5 All Species: 32.73
Human Site: S657 Identified Species: 48
UniProt: O75582 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75582 NP_004746.2 802 89865 S657 G E A W K N V S Q E A K D L I
Chimpanzee Pan troglodytes XP_001140389 894 100719 S749 G E A W K N V S Q E A K D L I
Rhesus Macaque Macaca mulatta XP_001088246 1054 117436 S909 G E A W K N V S Q E A K D L I
Dog Lupus familis XP_547953 806 90703 S664 G E A W K N V S Q E A K D L I
Cat Felis silvestris
Mouse Mus musculus Q9Z2B9 773 85721 F633 C K I R E G R F S L D G E A W
Rat Rattus norvegicus Q63531 735 82865 K587 F V A P E V L K R Q G Y D E G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506738 716 80894 S574 G E A W K N V S Q E A K D L I
Chicken Gallus gallus Q5F3L1 789 89022 S647 G E A W K N V S E E A K E L I
Frog Xenopus laevis P10665 733 82620 G592 K R Q G Y D E G C D I W S L G
Zebra Danio Brachydanio rerio Q6PFQ0 740 83378 V604 C D I W S L G V L L Y T M L A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V3I5 1207 137026 S856 S M R W E S A S P A F R H L V
Honey Bee Apis mellifera XP_395099 910 102507 K676 N L A R Q V A K G L L T V D P
Nematode Worm Caenorhab. elegans Q18846 772 87050 S623 G D A W T N V S A D A K N L I
Sea Urchin Strong. purpuratus XP_786494 918 102561 S617 G E E W N S V S T P A K D L I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q39030 471 53019 P336 E M L T G K P P F L G S K G K
Baker's Yeast Sacchar. cerevisiae P18961 677 76646 Y542 M M T G L P P Y Y D E N V P V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 88.1 75 93.1 N.A. 62.8 41 N.A. 82.1 89.4 40 40.5 N.A. 28.5 45.7 46.8 53.3
Protein Similarity: 100 88.5 75.1 95.1 N.A. 76.6 57.9 N.A. 86.1 94.6 57.4 57.3 N.A. 40 62.3 63 66.2
P-Site Identity: 100 100 100 100 N.A. 0 13.3 N.A. 100 86.6 6.6 13.3 N.A. 20 6.6 66.6 66.6
P-Site Similarity: 100 100 100 100 N.A. 20 40 N.A. 100 100 20 20 N.A. 46.6 13.3 86.6 73.3
Percent
Protein Identity: N.A. N.A. N.A. 21.2 21.5 N.A.
Protein Similarity: N.A. N.A. N.A. 35 38.5 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 57 0 0 0 13 0 7 7 50 0 0 7 7 % A
% Cys: 13 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % C
% Asp: 0 13 0 0 0 7 0 0 0 19 7 0 44 7 0 % D
% Glu: 7 44 7 0 19 0 7 0 7 38 7 0 13 7 0 % E
% Phe: 7 0 0 0 0 0 0 7 7 0 7 0 0 0 0 % F
% Gly: 50 0 0 13 7 7 7 7 7 0 13 7 0 7 13 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % H
% Ile: 0 0 13 0 0 0 0 0 0 0 7 0 0 0 50 % I
% Lys: 7 7 0 0 38 7 0 13 0 0 0 50 7 0 7 % K
% Leu: 0 7 7 0 7 7 7 0 7 25 7 0 0 69 0 % L
% Met: 7 19 0 0 0 0 0 0 0 0 0 0 7 0 0 % M
% Asn: 7 0 0 0 7 44 0 0 0 0 0 7 7 0 0 % N
% Pro: 0 0 0 7 0 7 13 7 7 7 0 0 0 7 7 % P
% Gln: 0 0 7 0 7 0 0 0 32 7 0 0 0 0 0 % Q
% Arg: 0 7 7 13 0 0 7 0 7 0 0 7 0 0 0 % R
% Ser: 7 0 0 0 7 13 0 57 7 0 0 7 7 0 0 % S
% Thr: 0 0 7 7 7 0 0 0 7 0 0 13 0 0 0 % T
% Val: 0 7 0 0 0 13 50 7 0 0 0 0 13 0 13 % V
% Trp: 0 0 0 63 0 0 0 0 0 0 0 7 0 0 7 % W
% Tyr: 0 0 0 0 7 0 0 7 7 0 7 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _