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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MED6 All Species: 36.36
Human Site: S169 Identified Species: 61.54
UniProt: O75586 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75586 NP_005457.2 246 28425 S169 A K R K E E P S S I F Q R Q R
Chimpanzee Pan troglodytes XP_001146303 246 28392 S169 A K R K E E P S S I F Q R Q R
Rhesus Macaque Macaca mulatta XP_001082932 246 28368 S169 A K R K E E P S S I F Q R Q R
Dog Lupus familis XP_547885 246 28431 S169 A K R K E E P S S I F Q R Q R
Cat Felis silvestris
Mouse Mus musculus Q921D4 246 28415 S169 A K R K E E P S S I F Q R Q R
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516878 154 17690 K104 P P R Y V Q Q K L G E K P V P
Chicken Gallus gallus NP_001152897 246 28334 S169 A K K K E E P S S I F Q R H R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6IQ63 254 29232 S169 S K R K E E P S S L F Q R Q R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q8MSX2 249 28356 G175 S A K D E N S G T L F Q K Q R
Honey Bee Apis mellifera XP_624826 213 24223 T163 A M A A K K E T P V R E E P S
Nematode Worm Caenorhab. elegans Q9N337 250 29388 S184 E E K L E D R S T N F Q K T R
Sea Urchin Strong. purpuratus XP_787850 312 34456 S166 K K P K E E L S S A F Q R K R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38782 295 32800 A236 S V R P T G G A N M A T V P S
Red Bread Mold Neurospora crassa Q9HED8 360 37718 T200 A G A A S G T T N Y T A S R T
Conservation
Percent
Protein Identity: 100 99.5 98.7 96.7 N.A. 95.1 N.A. N.A. 54.8 88.6 N.A. 76.3 N.A. 45.7 52.4 32.7 46.1
Protein Similarity: 100 100 99.1 97.5 N.A. 97.9 N.A. N.A. 58.1 94.7 N.A. 85 N.A. 63.4 66.6 55.2 59.6
P-Site Identity: 100 100 100 100 N.A. 100 N.A. N.A. 6.6 86.6 N.A. 86.6 N.A. 33.3 6.6 33.3 66.6
P-Site Similarity: 100 100 100 100 N.A. 100 N.A. N.A. 20 93.3 N.A. 100 N.A. 66.6 40 66.6 73.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22.7 24.1
Protein Similarity: N.A. N.A. N.A. N.A. 34.2 39.7
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 58 8 15 15 0 0 0 8 0 8 8 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 0 8 0 0 0 0 0 0 0 0 0 % D
% Glu: 8 8 0 0 72 58 8 0 0 0 8 8 8 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 72 0 0 0 0 % F
% Gly: 0 8 0 0 0 15 8 8 0 8 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 43 0 0 0 0 0 % I
% Lys: 8 58 22 58 8 8 0 8 0 0 0 8 15 8 0 % K
% Leu: 0 0 0 8 0 0 8 0 8 15 0 0 0 0 0 % L
% Met: 0 8 0 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 8 0 0 15 8 0 0 0 0 0 % N
% Pro: 8 8 8 8 0 0 50 0 8 0 0 0 8 15 8 % P
% Gln: 0 0 0 0 0 8 8 0 0 0 0 72 0 50 0 % Q
% Arg: 0 0 58 0 0 0 8 0 0 0 8 0 58 8 72 % R
% Ser: 22 0 0 0 8 0 8 65 58 0 0 0 8 0 15 % S
% Thr: 0 0 0 0 8 0 8 15 15 0 8 8 0 8 8 % T
% Val: 0 8 0 0 8 0 0 0 0 8 0 0 8 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _