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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MED6
All Species:
36.67
Human Site:
S170
Identified Species:
62.05
UniProt:
O75586
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75586
NP_005457.2
246
28425
S170
K
R
K
E
E
P
S
S
I
F
Q
R
Q
R
V
Chimpanzee
Pan troglodytes
XP_001146303
246
28392
S170
K
R
K
E
E
P
S
S
I
F
Q
R
Q
R
V
Rhesus Macaque
Macaca mulatta
XP_001082932
246
28368
S170
K
R
K
E
E
P
S
S
I
F
Q
R
Q
R
V
Dog
Lupus familis
XP_547885
246
28431
S170
K
R
K
E
E
P
S
S
I
F
Q
R
Q
R
V
Cat
Felis silvestris
Mouse
Mus musculus
Q921D4
246
28415
S170
K
R
K
E
E
P
S
S
I
F
Q
R
Q
R
V
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516878
154
17690
L105
P
R
Y
V
Q
Q
K
L
G
E
K
P
V
P
V
Chicken
Gallus gallus
NP_001152897
246
28334
S170
K
K
K
E
E
P
S
S
I
F
Q
R
H
R
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6IQ63
254
29232
S170
K
R
K
E
E
P
S
S
L
F
Q
R
Q
R
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q8MSX2
249
28356
T176
A
K
D
E
N
S
G
T
L
F
Q
K
Q
R
V
Honey Bee
Apis mellifera
XP_624826
213
24223
P164
M
A
A
K
K
E
T
P
V
R
E
E
P
S
S
Nematode Worm
Caenorhab. elegans
Q9N337
250
29388
T185
E
K
L
E
D
R
S
T
N
F
Q
K
T
R
T
Sea Urchin
Strong. purpuratus
XP_787850
312
34456
S167
K
P
K
E
E
L
S
S
A
F
Q
R
K
R
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38782
295
32800
N237
V
R
P
T
G
G
A
N
M
A
T
V
P
S
T
Red Bread Mold
Neurospora crassa
Q9HED8
360
37718
N201
G
A
A
S
G
T
T
N
Y
T
A
S
R
T
A
Conservation
Percent
Protein Identity:
100
99.5
98.7
96.7
N.A.
95.1
N.A.
N.A.
54.8
88.6
N.A.
76.3
N.A.
45.7
52.4
32.7
46.1
Protein Similarity:
100
100
99.1
97.5
N.A.
97.9
N.A.
N.A.
58.1
94.7
N.A.
85
N.A.
63.4
66.6
55.2
59.6
P-Site Identity:
100
100
100
100
N.A.
100
N.A.
N.A.
13.3
86.6
N.A.
93.3
N.A.
40
0
33.3
73.3
P-Site Similarity:
100
100
100
100
N.A.
100
N.A.
N.A.
26.6
93.3
N.A.
100
N.A.
66.6
33.3
66.6
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.7
24.1
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
34.2
39.7
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
15
15
0
0
0
8
0
8
8
8
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
8
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
8
0
0
72
58
8
0
0
0
8
8
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
72
0
0
0
0
0
% F
% Gly:
8
0
0
0
15
8
8
0
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
43
0
0
0
0
0
0
% I
% Lys:
58
22
58
8
8
0
8
0
0
0
8
15
8
0
0
% K
% Leu:
0
0
8
0
0
8
0
8
15
0
0
0
0
0
0
% L
% Met:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
15
8
0
0
0
0
0
0
% N
% Pro:
8
8
8
0
0
50
0
8
0
0
0
8
15
8
0
% P
% Gln:
0
0
0
0
8
8
0
0
0
0
72
0
50
0
0
% Q
% Arg:
0
58
0
0
0
8
0
0
0
8
0
58
8
72
0
% R
% Ser:
0
0
0
8
0
8
65
58
0
0
0
8
0
15
8
% S
% Thr:
0
0
0
8
0
8
15
15
0
8
8
0
8
8
15
% T
% Val:
8
0
0
8
0
0
0
0
8
0
0
8
8
0
72
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _