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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TIPRL All Species: 26.36
Human Site: S230 Identified Species: 44.62
UniProt: O75663 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75663 NP_001026970.1 272 31444 S230 S L M H V P P S L F T E P N E
Chimpanzee Pan troglodytes XP_513978 271 31294 S229 S L M H V P P S L F T E P N E
Rhesus Macaque Macaca mulatta XP_001091944 277 32074 S235 N I K H V P P S L F T E P N E
Dog Lupus familis XP_537207 473 52600 S431 N L M H V S P S L F T E P N E
Cat Felis silvestris
Mouse Mus musculus Q8BH58 271 31235 S230 N L M H V P P S L F T E P N E
Rat Rattus norvegicus A2VCX1 271 31206 S230 N L M H V P P S L F T E P N E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_416593 274 31546 S229 S L K H V P P S L F T E P N E
Frog Xenopus laevis Q6IRA8 259 29963 L224 K E S K I S N L S H V P P P L
Zebra Danio Brachydanio rerio NP_956957 269 30986 A233 D L Q H I P P A V Y T D P N E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_608377 272 32319 E236 L K E Y I H R E A P C T E L Q
Honey Bee Apis mellifera XP_396151 311 35842 L252 E I R A P P S L F I E P S E I
Nematode Worm Caenorhab. elegans P34274 281 32890 V248 K Y G N L G H V D P E E L L D
Sea Urchin Strong. purpuratus XP_791850 266 30474 E234 S I Q A L G L E P H E L Q D P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q12199 356 41001 L324 D V L A K H R L S Q S H D P K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 92.4 54.9 N.A. 96.6 95.9 N.A. N.A. 79.9 76.4 66.9 N.A. 41.9 42.4 38.4 48.1
Protein Similarity: 100 99.6 95.3 56.6 N.A. 98.1 97.7 N.A. N.A. 88.6 86.7 82.3 N.A. 61.7 64.3 56.9 68.3
P-Site Identity: 100 100 80 86.6 N.A. 93.3 93.3 N.A. N.A. 93.3 6.6 53.3 N.A. 0 6.6 6.6 6.6
P-Site Similarity: 100 100 93.3 93.3 N.A. 100 100 N.A. N.A. 93.3 13.3 86.6 N.A. 20 13.3 26.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 27.8 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 43.5 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 22 0 0 0 8 8 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 15 0 0 0 0 0 0 0 8 0 0 8 8 8 8 % D
% Glu: 8 8 8 0 0 0 0 15 0 0 22 58 8 8 58 % E
% Phe: 0 0 0 0 0 0 0 0 8 50 0 0 0 0 0 % F
% Gly: 0 0 8 0 0 15 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 58 0 15 8 0 0 15 0 8 0 0 0 % H
% Ile: 0 22 0 0 22 0 0 0 0 8 0 0 0 0 8 % I
% Lys: 15 8 15 8 8 0 0 0 0 0 0 0 0 0 8 % K
% Leu: 8 50 8 0 15 0 8 22 50 0 0 8 8 15 8 % L
% Met: 0 0 36 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 29 0 0 8 0 0 8 0 0 0 0 0 0 58 0 % N
% Pro: 0 0 0 0 8 58 58 0 8 15 0 15 65 15 8 % P
% Gln: 0 0 15 0 0 0 0 0 0 8 0 0 8 0 8 % Q
% Arg: 0 0 8 0 0 0 15 0 0 0 0 0 0 0 0 % R
% Ser: 29 0 8 0 0 15 8 50 15 0 8 0 8 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 58 8 0 0 0 % T
% Val: 0 8 0 0 50 0 0 8 8 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 8 0 0 0 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _