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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RPS6KA4
All Species:
19.7
Human Site:
S258
Identified Species:
28.89
UniProt:
O75676
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75676
NP_001006945.1
772
85606
S258
S
R
R
I
L
K
C
S
P
P
F
P
P
R
I
Chimpanzee
Pan troglodytes
XP_508900
901
98668
S387
S
R
R
I
L
K
C
S
P
P
F
P
P
R
I
Rhesus Macaque
Macaca mulatta
XP_001114877
772
85557
S258
S
R
R
I
L
K
C
S
P
P
F
P
P
R
I
Dog
Lupus familis
XP_854926
772
85603
S258
S
R
R
I
L
K
C
S
P
P
F
P
P
R
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2B9
773
85721
S258
S
R
R
I
L
K
C
S
P
P
F
P
L
R
I
Rat
Rattus norvegicus
Q63531
735
82865
F284
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506738
716
80894
P249
D
L
A
A
K
K
M
P
A
P
F
K
P
V
I
Chicken
Gallus gallus
Q5F3L1
789
89022
S264
I
S
R
R
I
L
K
S
E
P
P
Y
P
Q
E
Frog
Xenopus laevis
P10665
733
82620
F284
A
K
L
G
M
P
Q
F
L
S
N
E
A
Q
S
Zebra Danio
Brachydanio rerio
Q6PFQ0
740
83378
F289
A
K
L
G
M
P
Q
F
L
S
L
E
A
Q
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3I5
1207
137026
E486
I
S
R
R
I
Q
K
E
Q
P
M
I
P
S
S
Honey Bee
Apis mellifera
XP_395099
910
102507
I289
Q
Q
D
I
S
R
R
I
L
K
T
D
P
P
I
Nematode Worm
Caenorhab. elegans
Q18846
772
87050
L266
G
Q
L
L
E
K
K
L
E
K
R
L
G
Y
N
Sea Urchin
Strong. purpuratus
XP_786494
918
102561
N280
H
S
F
F
K
G
L
N
W
D
D
V
A
A
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39030
471
53019
V32
S
I
S
P
P
K
S
V
L
G
D
N
L
E
L
Baker's Yeast
Sacchar. cerevisiae
P18961
677
76646
V240
N
K
I
S
T
F
D
V
T
R
K
L
R
F
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.4
98.6
96.7
N.A.
95.8
41.3
N.A.
56
64
41
41.9
N.A.
27
45.1
48.1
48.2
Protein Similarity:
100
85.6
98.9
98
N.A.
96.7
60.6
N.A.
71.6
78.4
59
60.3
N.A.
38.9
60.1
64.3
61.8
P-Site Identity:
100
100
100
100
N.A.
93.3
0
N.A.
33.3
26.6
0
0
N.A.
20
20
6.6
0
P-Site Similarity:
100
100
100
100
N.A.
93.3
26.6
N.A.
33.3
40
26.6
26.6
N.A.
33.3
33.3
20
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.4
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35.6
37.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
19
0
7
7
0
0
0
0
7
0
0
0
25
7
0
% A
% Cys:
0
0
0
0
0
0
32
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
7
0
0
0
7
0
0
7
13
7
0
0
0
% D
% Glu:
0
0
0
0
7
0
0
7
13
0
0
19
0
7
7
% E
% Phe:
0
0
7
7
0
7
0
19
0
0
38
0
0
7
0
% F
% Gly:
7
0
0
19
0
7
0
0
0
7
0
0
7
0
7
% G
% His:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
13
7
7
38
13
0
0
7
0
0
0
7
0
0
44
% I
% Lys:
0
25
0
0
13
50
19
0
0
13
7
7
0
0
7
% K
% Leu:
0
7
25
7
32
7
7
7
32
0
7
13
13
0
13
% L
% Met:
0
0
0
0
19
0
7
0
0
0
7
0
0
0
0
% M
% Asn:
7
0
0
0
0
0
0
7
0
0
7
7
0
0
7
% N
% Pro:
0
0
0
7
7
19
0
7
32
50
7
32
50
7
0
% P
% Gln:
7
13
0
0
0
7
19
0
7
0
0
0
0
25
0
% Q
% Arg:
0
32
44
13
0
7
7
0
0
7
7
0
7
32
0
% R
% Ser:
38
19
7
7
7
0
7
38
0
19
0
0
0
7
19
% S
% Thr:
0
0
0
0
7
0
0
0
7
0
13
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
13
0
0
0
7
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
7
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _