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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RPS6KA4
All Species:
33.94
Human Site:
S423
Identified Species:
49.78
UniProt:
O75676
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75676
NP_001006945.1
772
85606
S423
A
L
G
Q
G
S
F
S
V
C
R
R
C
R
Q
Chimpanzee
Pan troglodytes
XP_508900
901
98668
S552
A
L
G
Q
G
S
F
S
V
C
R
R
C
R
Q
Rhesus Macaque
Macaca mulatta
XP_001114877
772
85557
S423
A
L
G
Q
G
S
F
S
V
C
R
R
C
R
Q
Dog
Lupus familis
XP_854926
772
85603
S424
A
L
G
Q
G
S
F
S
V
C
R
R
C
R
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2B9
773
85721
S423
A
L
G
Q
G
S
F
S
V
C
R
R
C
R
Q
Rat
Rattus norvegicus
Q63531
735
82865
A398
S
K
P
R
A
T
Q
A
P
L
H
S
V
V
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506738
716
80894
C360
S
F
S
I
C
R
K
C
L
H
K
K
S
N
Q
Chicken
Gallus gallus
Q5F3L1
789
89022
S428
P
L
G
E
G
S
F
S
I
C
R
K
C
L
H
Frog
Xenopus laevis
P10665
733
82620
S401
T
S
S
P
P
V
L
S
V
P
K
T
H
S
K
Zebra Danio
Brachydanio rerio
Q6PFQ0
740
83378
P405
A
P
L
V
N
I
L
P
I
V
Q
V
H
G
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3I5
1207
137026
C637
S
N
G
A
Y
G
T
C
H
F
V
V
D
S
S
Honey Bee
Apis mellifera
XP_395099
910
102507
S463
A
L
G
D
G
S
F
S
V
C
R
K
C
R
H
Nematode Worm
Caenorhab. elegans
Q18846
772
87050
S394
L
L
G
K
G
A
F
S
V
V
R
R
C
E
R
Sea Urchin
Strong. purpuratus
XP_786494
918
102561
S397
P
I
G
D
G
S
F
S
I
C
R
R
C
T
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39030
471
53019
E141
V
V
G
I
E
D
F
E
V
L
K
V
V
G
Q
Baker's Yeast
Sacchar. cerevisiae
P18961
677
76646
V349
D
D
F
D
L
L
K
V
I
G
K
G
S
F
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.4
98.6
96.7
N.A.
95.8
41.3
N.A.
56
64
41
41.9
N.A.
27
45.1
48.1
48.2
Protein Similarity:
100
85.6
98.9
98
N.A.
96.7
60.6
N.A.
71.6
78.4
59
60.3
N.A.
38.9
60.1
64.3
61.8
P-Site Identity:
100
100
100
100
N.A.
100
6.6
N.A.
6.6
60
13.3
6.6
N.A.
6.6
80
60
60
P-Site Similarity:
100
100
100
100
N.A.
100
33.3
N.A.
33.3
80
26.6
20
N.A.
13.3
86.6
80
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.4
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35.6
37.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
44
0
0
7
7
7
0
7
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
7
0
0
13
0
50
0
0
57
0
0
% C
% Asp:
7
7
0
19
0
7
0
0
0
0
0
0
7
0
0
% D
% Glu:
0
0
0
7
7
0
0
7
0
0
0
0
0
7
0
% E
% Phe:
0
7
7
0
0
0
63
0
0
7
0
0
0
7
0
% F
% Gly:
0
0
69
0
57
7
0
0
0
7
0
7
0
13
7
% G
% His:
0
0
0
0
0
0
0
0
7
7
7
0
13
0
19
% H
% Ile:
0
7
0
13
0
7
0
0
25
0
0
0
0
0
0
% I
% Lys:
0
7
0
7
0
0
13
0
0
0
25
19
0
0
7
% K
% Leu:
7
50
7
0
7
7
13
0
7
13
0
0
0
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
0
7
0
0
0
0
0
0
0
0
7
0
% N
% Pro:
13
7
7
7
7
0
0
7
7
7
0
0
0
0
0
% P
% Gln:
0
0
0
32
0
0
7
0
0
0
7
0
0
0
50
% Q
% Arg:
0
0
0
7
0
7
0
0
0
0
57
44
0
38
7
% R
% Ser:
19
7
13
0
0
50
0
63
0
0
0
7
13
13
13
% S
% Thr:
7
0
0
0
0
7
7
0
0
0
0
7
0
7
0
% T
% Val:
7
7
0
7
0
7
0
7
57
13
7
19
13
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _