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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RPS6KA4 All Species: 24.24
Human Site: S700 Identified Species: 35.56
UniProt: O75676 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75676 NP_001006945.1 772 85606 S700 S S G P A V R S G L N A T F M
Chimpanzee Pan troglodytes XP_508900 901 98668 S829 S S G P A V R S G L N A T F M
Rhesus Macaque Macaca mulatta XP_001114877 772 85557 S700 S S G P A V R S G L N A T F M
Dog Lupus familis XP_854926 772 85603 S701 S S G P A V R S G L N A T F M
Cat Felis silvestris
Mouse Mus musculus Q9Z2B9 773 85721 S700 S S G P A V R S G L N A T F M
Rat Rattus norvegicus Q63531 735 82865 Q662 M L H V D P H Q R L T A K Q V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506738 716 80894 T630 S S G A A V H T C V K A T F H
Chicken Gallus gallus Q5F3L1 789 89022 T703 S S G A A V H T Y V K A T F H
Frog Xenopus laevis P10665 733 82620 K660 M L H V D P H K R L T A K Q V
Zebra Danio Brachydanio rerio Q6PFQ0 740 83378 V671 H R Y T A E Q V L K H S W I A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V3I5 1207 137026 M912 V D L S E D T M E Q P T G G M
Honey Bee Apis mellifera XP_395099 910 102507 L732 E K P E G F R L R E V D G A R
Nematode Worm Caenorhab. elegans Q18846 772 87050 E679 S A D E T F N E T L R A F L H
Sea Urchin Strong. purpuratus XP_786494 918 102561 R673 S C A S I Q K R V K A T M R A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q39030 471 53019 K402 F K A I N W K K L E A R E V Q
Baker's Yeast Sacchar. cerevisiae P18961 677 76646 L608 D I S W K K L L L K G Y I P P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85.4 98.6 96.7 N.A. 95.8 41.3 N.A. 56 64 41 41.9 N.A. 27 45.1 48.1 48.2
Protein Similarity: 100 85.6 98.9 98 N.A. 96.7 60.6 N.A. 71.6 78.4 59 60.3 N.A. 38.9 60.1 64.3 61.8
P-Site Identity: 100 100 100 100 N.A. 100 13.3 N.A. 53.3 53.3 13.3 6.6 N.A. 6.6 6.6 20 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 20 N.A. 66.6 66.6 20 26.6 N.A. 6.6 6.6 26.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. 20.4 21.2 N.A.
Protein Similarity: N.A. N.A. N.A. 35.6 37.5 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 13 13 50 0 0 0 0 0 13 63 0 7 13 % A
% Cys: 0 7 0 0 0 0 0 0 7 0 0 0 0 0 0 % C
% Asp: 7 7 7 0 13 7 0 0 0 0 0 7 0 0 0 % D
% Glu: 7 0 0 13 7 7 0 7 7 13 0 0 7 0 0 % E
% Phe: 7 0 0 0 0 13 0 0 0 0 0 0 7 44 0 % F
% Gly: 0 0 44 0 7 0 0 0 32 0 7 0 13 7 0 % G
% His: 7 0 13 0 0 0 25 0 0 0 7 0 0 0 19 % H
% Ile: 0 7 0 7 7 0 0 0 0 0 0 0 7 7 0 % I
% Lys: 0 13 0 0 7 7 13 13 0 19 13 0 13 0 0 % K
% Leu: 0 13 7 0 0 0 7 13 19 50 0 0 0 7 0 % L
% Met: 13 0 0 0 0 0 0 7 0 0 0 0 7 0 38 % M
% Asn: 0 0 0 0 7 0 7 0 0 0 32 0 0 0 0 % N
% Pro: 0 0 7 32 0 13 0 0 0 0 7 0 0 7 7 % P
% Gln: 0 0 0 0 0 7 7 7 0 7 0 0 0 13 7 % Q
% Arg: 0 7 0 0 0 0 38 7 19 0 7 7 0 7 7 % R
% Ser: 57 44 7 13 0 0 0 32 0 0 0 7 0 0 0 % S
% Thr: 0 0 0 7 7 0 7 13 7 0 13 13 44 0 0 % T
% Val: 7 0 0 13 0 44 0 7 7 13 7 0 0 7 13 % V
% Trp: 0 0 0 7 0 7 0 0 0 0 0 0 7 0 0 % W
% Tyr: 0 0 7 0 0 0 0 0 7 0 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _