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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RPS6KA4
All Species:
23.03
Human Site:
S721
Identified Species:
33.78
UniProt:
O75676
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75676
NP_001006945.1
772
85606
S721
R
E
G
F
F
L
K
S
V
E
N
A
P
L
A
Chimpanzee
Pan troglodytes
XP_508900
901
98668
S850
R
E
G
F
F
L
K
S
V
E
N
A
P
L
A
Rhesus Macaque
Macaca mulatta
XP_001114877
772
85557
S721
R
E
G
F
F
L
K
S
V
E
N
A
P
L
A
Dog
Lupus familis
XP_854926
772
85603
S722
R
E
G
F
F
L
K
S
V
E
N
A
P
L
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2B9
773
85721
S721
R
E
G
F
F
L
K
S
V
E
N
A
P
L
A
Rat
Rattus norvegicus
Q63531
735
82865
S684
Q
K
D
K
L
P
Q
S
Q
L
S
H
Q
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506738
716
80894
N651
R
E
G
F
C
L
Q
N
V
D
K
A
P
L
A
Chicken
Gallus gallus
Q5F3L1
789
89022
N724
R
E
G
F
C
L
Q
N
V
D
K
A
P
L
A
Frog
Xenopus laevis
P10665
733
82620
S682
K
R
D
A
L
P
Q
S
Q
L
N
R
Q
D
V
Zebra Danio
Brachydanio rerio
Q6PFQ0
740
83378
H691
P
H
F
Q
L
T
R
H
E
A
P
H
L
V
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3I5
1207
137026
T1057
V
Q
P
V
S
V
A
T
Y
E
D
S
K
A
S
Honey Bee
Apis mellifera
XP_395099
910
102507
N844
S
K
K
C
K
K
Q
N
V
Q
C
T
E
I
Y
Nematode Worm
Caenorhab. elegans
Q18846
772
87050
A717
R
Q
S
G
D
K
D
A
S
G
N
S
K
N
S
Sea Urchin
Strong. purpuratus
XP_786494
918
102561
D693
R
E
G
F
L
L
T
D
V
S
N
A
P
L
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39030
471
53019
I422
A
V
S
G
R
Q
C
I
A
N
F
D
K
C
W
Baker's Yeast
Sacchar. cerevisiae
P18961
677
76646
N628
K
S
E
I
D
T
A
N
F
D
Q
E
F
T
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.4
98.6
96.7
N.A.
95.8
41.3
N.A.
56
64
41
41.9
N.A.
27
45.1
48.1
48.2
Protein Similarity:
100
85.6
98.9
98
N.A.
96.7
60.6
N.A.
71.6
78.4
59
60.3
N.A.
38.9
60.1
64.3
61.8
P-Site Identity:
100
100
100
100
N.A.
100
6.6
N.A.
66.6
66.6
13.3
0
N.A.
6.6
6.6
13.3
73.3
P-Site Similarity:
100
100
100
100
N.A.
100
33.3
N.A.
86.6
86.6
26.6
13.3
N.A.
46.6
40
40
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.4
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35.6
37.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
7
0
0
13
7
7
7
0
50
0
7
50
% A
% Cys:
0
0
0
7
13
0
7
0
0
0
7
0
0
7
0
% C
% Asp:
0
0
13
0
13
0
7
7
0
19
7
7
0
13
0
% D
% Glu:
0
50
7
0
0
0
0
0
7
38
0
7
7
0
0
% E
% Phe:
0
0
7
50
32
0
0
0
7
0
7
0
7
0
0
% F
% Gly:
0
0
50
13
0
0
0
0
0
7
0
0
0
0
0
% G
% His:
0
7
0
0
0
0
0
7
0
0
0
13
0
0
0
% H
% Ile:
0
0
0
7
0
0
0
7
0
0
0
0
0
7
0
% I
% Lys:
13
13
7
7
7
13
32
0
0
0
13
0
19
0
13
% K
% Leu:
0
0
0
0
25
50
0
0
0
13
0
0
7
50
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
25
0
7
50
0
0
7
0
% N
% Pro:
7
0
7
0
0
13
0
0
0
0
7
0
50
0
0
% P
% Gln:
7
13
0
7
0
7
32
0
13
7
7
0
13
0
0
% Q
% Arg:
57
7
0
0
7
0
7
0
0
0
0
7
0
0
0
% R
% Ser:
7
7
13
0
7
0
0
44
7
7
7
13
0
0
13
% S
% Thr:
0
0
0
0
0
13
7
7
0
0
0
7
0
7
0
% T
% Val:
7
7
0
7
0
7
0
0
57
0
0
0
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _