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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RPS6KA4
All Species:
27.27
Human Site:
S741
Identified Species:
40
UniProt:
O75676
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75676
NP_001006945.1
772
85606
S741
K
L
R
S
A
T
A
S
R
R
G
S
P
A
P
Chimpanzee
Pan troglodytes
XP_508900
901
98668
S870
K
L
R
S
A
T
A
S
R
R
G
S
P
A
P
Rhesus Macaque
Macaca mulatta
XP_001114877
772
85557
S741
K
L
R
S
A
T
A
S
R
R
G
S
P
A
P
Dog
Lupus familis
XP_854926
772
85603
T741
Q
K
L
R
S
A
A
T
S
R
R
V
S
P
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2B9
773
85721
S741
K
L
R
S
A
A
A
S
R
R
G
S
P
V
P
Rat
Rattus norvegicus
Q63531
735
82865
S703
G
G
M
A
A
T
Y
S
A
L
S
S
S
K
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506738
716
80894
T672
K
T
S
T
S
T
E
T
R
S
S
S
S
E
S
Chicken
Gallus gallus
Q5F3L1
789
89022
T745
K
T
S
T
S
T
E
T
R
S
S
S
S
E
S
Frog
Xenopus laevis
P10665
733
82620
S701
G
A
M
A
A
T
Y
S
A
L
N
S
S
K
P
Zebra Danio
Brachydanio rerio
Q6PFQ0
740
83378
H710
A
T
Y
S
A
L
N
H
K
T
C
K
P
V
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3I5
1207
137026
K1165
K
L
D
H
A
Y
E
K
P
L
T
F
P
R
P
Honey Bee
Apis mellifera
XP_395099
910
102507
N872
K
L
E
E
Q
T
I
N
E
D
E
L
S
V
L
Nematode Worm
Caenorhab. elegans
Q18846
772
87050
S742
E
Q
E
A
E
M
T
S
S
T
S
R
P
S
N
Sea Urchin
Strong. purpuratus
XP_786494
918
102561
T713
K
K
D
S
S
T
E
T
R
S
S
S
S
E
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39030
471
53019
S441
V
L
D
S
P
A
S
S
P
N
S
D
A
K
A
Baker's Yeast
Sacchar. cerevisiae
P18961
677
76646
L647
D
S
V
V
D
E
Y
L
S
A
S
I
Q
K
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.4
98.6
96.7
N.A.
95.8
41.3
N.A.
56
64
41
41.9
N.A.
27
45.1
48.1
48.2
Protein Similarity:
100
85.6
98.9
98
N.A.
96.7
60.6
N.A.
71.6
78.4
59
60.3
N.A.
38.9
60.1
64.3
61.8
P-Site Identity:
100
100
100
13.3
N.A.
86.6
33.3
N.A.
26.6
26.6
33.3
20
N.A.
33.3
20
13.3
33.3
P-Site Similarity:
100
100
100
33.3
N.A.
86.6
40
N.A.
46.6
46.6
40
26.6
N.A.
33.3
26.6
33.3
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.4
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35.6
37.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
19
50
19
32
0
13
7
0
0
7
19
13
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
7
0
19
0
7
0
0
0
0
7
0
7
0
0
0
% D
% Glu:
7
0
13
7
7
7
25
0
7
0
7
0
0
19
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% F
% Gly:
13
7
0
0
0
0
0
0
0
0
25
0
0
0
0
% G
% His:
0
0
0
7
0
0
0
7
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
7
0
0
0
0
7
0
0
0
% I
% Lys:
57
13
0
0
0
0
0
7
7
0
0
7
0
25
0
% K
% Leu:
0
44
7
0
0
7
0
7
0
19
0
7
0
0
13
% L
% Met:
0
0
13
0
0
7
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
7
7
0
7
7
0
0
0
7
% N
% Pro:
0
0
0
0
7
0
0
0
13
0
0
0
44
7
44
% P
% Gln:
7
7
0
0
7
0
0
0
0
0
0
0
7
0
7
% Q
% Arg:
0
0
25
7
0
0
0
0
44
32
7
7
0
7
0
% R
% Ser:
0
7
13
44
25
0
7
50
19
19
44
57
44
7
19
% S
% Thr:
0
19
0
13
0
57
7
25
0
13
7
0
0
0
0
% T
% Val:
7
0
7
7
0
0
0
0
0
0
0
7
0
19
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
7
19
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _