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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RPS6KA4
All Species:
29.7
Human Site:
Y586
Identified Species:
43.56
UniProt:
O75676
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75676
NP_001006945.1
772
85606
Y586
E
L
L
A
Q
Q
G
Y
D
E
S
C
D
L
W
Chimpanzee
Pan troglodytes
XP_508900
901
98668
Y715
E
L
L
A
Q
Q
G
Y
D
E
S
C
D
L
W
Rhesus Macaque
Macaca mulatta
XP_001114877
772
85557
Y586
E
L
L
A
Q
Q
G
Y
D
E
S
C
D
L
W
Dog
Lupus familis
XP_854926
772
85603
Y587
E
L
L
A
Q
Q
G
Y
D
E
S
C
D
L
W
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2B9
773
85721
Y586
E
L
L
A
Q
Q
G
Y
D
E
S
C
D
L
W
Rat
Rattus norvegicus
Q63531
735
82865
G548
I
L
Y
V
D
E
S
G
N
P
E
C
L
R
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506738
716
80894
Y516
E
L
L
N
H
N
G
Y
D
E
S
C
D
L
W
Chicken
Gallus gallus
Q5F3L1
789
89022
Y589
E
L
F
N
H
N
G
Y
D
E
S
C
D
L
W
Frog
Xenopus laevis
P10665
733
82620
G546
I
L
Y
V
D
E
S
G
D
P
E
S
I
R
I
Zebra Danio
Brachydanio rerio
Q6PFQ0
740
83378
I557
G
N
P
D
S
I
R
I
C
D
F
G
F
A
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3I5
1207
137026
P798
A
N
L
V
T
Y
S
P
A
V
D
I
Y
G
L
Honey Bee
Apis mellifera
XP_395099
910
102507
Y618
E
V
I
A
R
Q
G
Y
D
Q
S
C
D
L
W
Nematode Worm
Caenorhab. elegans
Q18846
772
87050
Q565
V
L
D
V
G
D
S
Q
P
E
Y
N
E
Q
C
Sea Urchin
Strong. purpuratus
XP_786494
918
102561
E559
R
A
Y
E
Q
D
G
E
Y
D
A
S
C
D
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39030
471
53019
F288
D
F
G
L
A
K
E
F
E
E
N
T
R
S
N
Baker's Yeast
Sacchar. cerevisiae
P18961
677
76646
K494
G
L
C
K
L
N
M
K
D
N
D
K
T
D
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.4
98.6
96.7
N.A.
95.8
41.3
N.A.
56
64
41
41.9
N.A.
27
45.1
48.1
48.2
Protein Similarity:
100
85.6
98.9
98
N.A.
96.7
60.6
N.A.
71.6
78.4
59
60.3
N.A.
38.9
60.1
64.3
61.8
P-Site Identity:
100
100
100
100
N.A.
100
13.3
N.A.
80
73.3
13.3
0
N.A.
6.6
73.3
13.3
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
26.6
N.A.
80
73.3
20
6.6
N.A.
6.6
100
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.4
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35.6
37.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
38
7
0
0
0
7
0
7
0
0
7
0
% A
% Cys:
0
0
7
0
0
0
0
0
7
0
0
57
7
0
7
% C
% Asp:
7
0
7
7
13
13
0
0
63
13
13
0
50
13
0
% D
% Glu:
50
0
0
7
0
13
7
7
7
57
13
0
7
0
0
% E
% Phe:
0
7
7
0
0
0
0
7
0
0
7
0
7
0
0
% F
% Gly:
13
0
7
0
7
0
57
13
0
0
0
7
0
7
0
% G
% His:
0
0
0
0
13
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
13
0
7
0
0
7
0
7
0
0
0
7
7
0
13
% I
% Lys:
0
0
0
7
0
7
0
7
0
0
0
7
0
0
7
% K
% Leu:
0
69
44
7
7
0
0
0
0
0
0
0
7
50
7
% L
% Met:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% M
% Asn:
0
13
0
13
0
19
0
0
7
7
7
7
0
0
7
% N
% Pro:
0
0
7
0
0
0
0
7
7
13
0
0
0
0
0
% P
% Gln:
0
0
0
0
38
38
0
7
0
7
0
0
0
7
0
% Q
% Arg:
7
0
0
0
7
0
7
0
0
0
0
0
7
13
0
% R
% Ser:
0
0
0
0
7
0
25
0
0
0
50
13
0
7
0
% S
% Thr:
0
0
0
0
7
0
0
0
0
0
0
7
7
0
7
% T
% Val:
7
7
0
25
0
0
0
0
0
7
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
50
% W
% Tyr:
0
0
19
0
0
7
0
50
7
0
7
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _