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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC25A12
All Species:
31.82
Human Site:
S423
Identified Species:
53.85
UniProt:
O75746
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75746
NP_003696.2
678
74762
S423
K
F
T
R
R
D
G
S
V
P
L
P
A
E
V
Chimpanzee
Pan troglodytes
XP_001145847
680
74987
S425
K
F
T
R
R
D
G
S
V
P
L
P
A
E
V
Rhesus Macaque
Macaca mulatta
XP_001085208
678
74724
S423
K
F
T
R
R
D
G
S
V
P
L
P
A
E
V
Dog
Lupus familis
XP_535962
678
74780
S423
K
F
T
R
R
D
G
S
I
P
L
L
A
E
I
Cat
Felis silvestris
Mouse
Mus musculus
Q8BH59
677
74551
S423
K
F
T
K
R
D
G
S
I
P
L
P
A
E
I
Rat
Rattus norvegicus
XP_342641
717
78438
S467
K
F
M
H
K
D
G
S
V
P
L
L
A
E
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514496
680
74679
S425
K
F
T
R
R
D
G
S
I
P
F
F
A
E
V
Chicken
Gallus gallus
XP_428938
642
70679
A404
E
I
L
A
G
G
C
A
G
A
S
Q
V
I
F
Frog
Xenopus laevis
Q7ZY36
473
52338
M240
I
I
T
G
L
K
Q
M
V
K
E
G
G
V
R
Zebra Danio
Brachydanio rerio
NP_997947
682
75371
T425
K
F
T
T
N
D
D
T
I
P
L
A
A
E
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VA73
695
76736
N438
K
L
T
D
K
K
G
N
I
P
T
W
A
E
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21153
707
78652
I466
K
F
T
K
D
G
K
I
P
L
Y
G
E
I
I
Sea Urchin
Strong. purpuratus
XP_785145
691
77086
T446
K
V
R
R
K
D
G
T
F
P
V
W
G
E
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12482
902
104286
K621
R
L
T
D
K
N
G
K
L
S
L
F
P
E
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
99.8
97.7
N.A.
96.7
72.5
N.A.
85.5
83.1
20.2
77.5
N.A.
57.1
N.A.
52
60.7
Protein Similarity:
100
99.4
99.8
98.9
N.A.
98.5
81.8
N.A.
89.8
89.3
34.2
86.9
N.A.
73.3
N.A.
68.7
74.1
P-Site Identity:
100
100
100
80
N.A.
80
66.6
N.A.
80
0
13.3
53.3
N.A.
46.6
N.A.
20
40
P-Site Similarity:
100
100
100
93.3
N.A.
100
80
N.A.
86.6
13.3
13.3
73.3
N.A.
66.6
N.A.
33.3
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
8
0
8
0
8
65
0
0
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
15
8
65
8
0
0
0
0
0
0
0
0
% D
% Glu:
8
0
0
0
0
0
0
0
0
0
8
0
8
79
0
% E
% Phe:
0
65
0
0
0
0
0
0
8
0
8
15
0
0
8
% F
% Gly:
0
0
0
8
8
15
72
0
8
0
0
15
15
0
0
% G
% His:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
15
0
0
0
0
0
8
36
0
0
0
0
15
43
% I
% Lys:
79
0
0
15
29
15
8
8
0
8
0
0
0
0
0
% K
% Leu:
0
15
8
0
8
0
0
0
8
8
58
15
0
0
0
% L
% Met:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
0
8
8
0
8
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
72
0
29
8
0
0
% P
% Gln:
0
0
0
0
0
0
8
0
0
0
0
8
0
0
0
% Q
% Arg:
8
0
8
43
43
0
0
0
0
0
0
0
0
0
8
% R
% Ser:
0
0
0
0
0
0
0
50
0
8
8
0
0
0
0
% S
% Thr:
0
0
79
8
0
0
0
15
0
0
8
0
0
0
0
% T
% Val:
0
8
0
0
0
0
0
0
36
0
8
0
8
8
36
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
15
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _