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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC25A12
All Species:
26.97
Human Site:
S558
Identified Species:
45.64
UniProt:
O75746
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75746
NP_003696.2
678
74762
S558
R
A
G
Q
T
T
Y
S
G
V
I
D
C
F
R
Chimpanzee
Pan troglodytes
XP_001145847
680
74987
S560
R
A
G
Q
T
T
Y
S
G
V
I
D
C
F
R
Rhesus Macaque
Macaca mulatta
XP_001085208
678
74724
S558
R
A
G
Q
T
T
Y
S
G
V
I
D
C
F
R
Dog
Lupus familis
XP_535962
678
74780
S558
R
A
G
Q
T
T
Y
S
G
V
I
D
C
F
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8BH59
677
74551
S558
R
A
G
Q
T
T
Y
S
G
V
V
D
C
F
R
Rat
Rattus norvegicus
XP_342641
717
78438
Q591
D
V
I
K
T
R
L
Q
V
A
A
R
A
G
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514496
680
74679
T560
R
A
G
Q
T
T
Y
T
G
V
I
D
C
F
R
Chicken
Gallus gallus
XP_428938
642
70679
A520
R
L
Q
V
A
A
R
A
G
Q
T
T
Y
S
G
Frog
Xenopus laevis
Q7ZY36
473
52338
Y356
N
I
L
G
I
I
P
Y
A
G
I
D
L
A
I
Zebra Danio
Brachydanio rerio
NP_997947
682
75371
N560
R
A
G
Q
T
T
Y
N
G
V
I
D
C
F
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VA73
695
76736
T573
R
S
G
Q
T
T
Y
T
G
V
W
D
A
T
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21153
707
78652
K586
V
T
P
A
D
V
I
K
T
R
L
Q
V
A
A
Sea Urchin
Strong. purpuratus
XP_785145
691
77086
A573
K
T
R
L
Q
V
E
A
R
R
G
Q
T
T
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12482
902
104286
N767
R
K
G
E
T
K
Y
N
G
I
F
H
A
I
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
99.8
97.7
N.A.
96.7
72.5
N.A.
85.5
83.1
20.2
77.5
N.A.
57.1
N.A.
52
60.7
Protein Similarity:
100
99.4
99.8
98.9
N.A.
98.5
81.8
N.A.
89.8
89.3
34.2
86.9
N.A.
73.3
N.A.
68.7
74.1
P-Site Identity:
100
100
100
100
N.A.
93.3
6.6
N.A.
93.3
13.3
13.3
93.3
N.A.
60
N.A.
0
0
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
100
20
13.3
100
N.A.
80
N.A.
6.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
50
0
8
8
8
0
15
8
8
8
0
22
15
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
50
0
0
% C
% Asp:
8
0
0
0
8
0
0
0
0
0
0
65
0
0
0
% D
% Glu:
0
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
0
0
50
0
% F
% Gly:
0
0
65
8
0
0
0
0
72
8
8
0
0
8
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
8
8
0
8
8
8
0
0
8
50
0
0
8
8
% I
% Lys:
8
8
0
8
0
8
0
8
0
0
0
0
0
0
8
% K
% Leu:
0
8
8
8
0
0
8
0
0
0
8
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
15
0
0
0
0
0
0
0
% N
% Pro:
0
0
8
0
0
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
58
8
0
0
8
0
8
0
15
0
0
8
% Q
% Arg:
72
0
8
0
0
8
8
0
8
15
0
8
0
0
58
% R
% Ser:
0
8
0
0
0
0
0
36
0
0
0
0
0
8
0
% S
% Thr:
0
15
0
0
72
58
0
15
8
0
8
8
8
15
0
% T
% Val:
8
8
0
8
0
15
0
0
8
58
8
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
65
8
0
0
0
0
8
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _