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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC25A12 All Species: 20
Human Site: T8 Identified Species: 33.85
UniProt: O75746 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75746 NP_003696.2 678 74762 T8 M A V K V Q T T K R G D P H E
Chimpanzee Pan troglodytes XP_001145847 680 74987 T10 E A C Q V Q T T K R G D P H E
Rhesus Macaque Macaca mulatta XP_001085208 678 74724 T8 M A V K V Q T T K R G D P H E
Dog Lupus familis XP_535962 678 74780 T8 M A V K V Q T T K R G D P H E
Cat Felis silvestris
Mouse Mus musculus Q8BH59 677 74551 T8 M A V K V H T T K R G D P H E
Rat Rattus norvegicus XP_342641 717 78438 T50 V A A W V A L T K R A D P A E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514496 680 74679 I10 M C T T A A I I H G A N H F L
Chicken Gallus gallus XP_428938 642 70679 K9 T P E D F V Q K Y L G L Y T D
Frog Xenopus laevis Q7ZY36 473 52338
Zebra Danio Brachydanio rerio NP_997947 682 75371 K9 A A K V Q L T K R A D P N D L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VA73 695 76736 L27 C Q E S P S L L K R A G T E K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q21153 707 78652 I49 T A I S Q R S I P R A N P D H
Sea Urchin Strong. purpuratus XP_785145 691 77086 V36 T R R A L H L V K R A D P V Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q12482 902 104286 G52 N S S K L T A G N G K P D T E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 99.8 97.7 N.A. 96.7 72.5 N.A. 85.5 83.1 20.2 77.5 N.A. 57.1 N.A. 52 60.7
Protein Similarity: 100 99.4 99.8 98.9 N.A. 98.5 81.8 N.A. 89.8 89.3 34.2 86.9 N.A. 73.3 N.A. 68.7 74.1
P-Site Identity: 100 80 100 100 N.A. 93.3 53.3 N.A. 6.6 6.6 0 13.3 N.A. 13.3 N.A. 20 26.6
P-Site Similarity: 100 86.6 100 100 N.A. 93.3 60 N.A. 13.3 13.3 0 20 N.A. 20 N.A. 46.6 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. 29 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 43.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 58 8 8 8 15 8 0 0 8 36 0 0 8 0 % A
% Cys: 8 8 8 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 0 0 0 0 0 0 8 50 8 15 8 % D
% Glu: 8 0 15 0 0 0 0 0 0 0 0 0 0 8 50 % E
% Phe: 0 0 0 0 8 0 0 0 0 0 0 0 0 8 0 % F
% Gly: 0 0 0 0 0 0 0 8 0 15 43 8 0 0 0 % G
% His: 0 0 0 0 0 15 0 0 8 0 0 0 8 36 8 % H
% Ile: 0 0 8 0 0 0 8 15 0 0 0 0 0 0 0 % I
% Lys: 0 0 8 36 0 0 0 15 58 0 8 0 0 0 8 % K
% Leu: 0 0 0 0 15 8 22 8 0 8 0 8 0 0 15 % L
% Met: 36 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 0 0 0 8 0 0 15 8 0 0 % N
% Pro: 0 8 0 0 8 0 0 0 8 0 0 15 58 0 0 % P
% Gln: 0 8 0 8 15 29 8 0 0 0 0 0 0 0 8 % Q
% Arg: 0 8 8 0 0 8 0 0 8 65 0 0 0 0 0 % R
% Ser: 0 8 8 15 0 8 8 0 0 0 0 0 0 0 0 % S
% Thr: 22 0 8 8 0 8 43 43 0 0 0 0 8 15 0 % T
% Val: 8 0 29 8 43 8 0 8 0 0 0 0 0 8 0 % V
% Trp: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 8 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _