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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC25A12
All Species:
26.36
Human Site:
Y278
Identified Species:
44.62
UniProt:
O75746
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75746
NP_003696.2
678
74762
Y278
L
Y
Q
L
A
D
L
Y
N
A
S
G
R
L
T
Chimpanzee
Pan troglodytes
XP_001145847
680
74987
Y280
L
Y
Q
L
A
D
L
Y
N
A
S
G
R
L
T
Rhesus Macaque
Macaca mulatta
XP_001085208
678
74724
Y278
L
Y
Q
L
A
D
L
Y
N
A
S
G
R
L
T
Dog
Lupus familis
XP_535962
678
74780
Y278
L
Y
Q
L
A
D
L
Y
N
A
T
G
R
L
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8BH59
677
74551
Y278
L
Y
Q
L
A
D
L
Y
N
A
S
G
R
L
T
Rat
Rattus norvegicus
XP_342641
717
78438
Y320
L
F
Q
L
A
D
L
Y
E
P
R
G
R
M
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514496
680
74679
Y280
L
Y
Q
L
A
D
L
Y
N
A
T
G
R
L
T
Chicken
Gallus gallus
XP_428938
642
70679
A263
I
E
R
V
A
P
L
A
E
G
A
L
P
Y
N
Frog
Xenopus laevis
Q7ZY36
473
52338
N101
A
F
T
S
L
D
K
N
K
D
G
K
I
E
S
Zebra Danio
Brachydanio rerio
NP_997947
682
75371
H279
L
F
Q
L
S
G
L
H
S
Q
T
G
R
L
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VA73
695
76736
V294
L
F
H
L
A
G
A
V
H
Q
A
G
R
I
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21153
707
78652
N319
L
F
H
L
S
E
L
N
H
P
G
R
K
T
L
Sea Urchin
Strong. purpuratus
XP_785145
691
77086
E306
L
F
H
I
C
C
L
E
E
S
V
G
R
V
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12482
902
104286
I376
Y
N
K
V
N
N
I
I
E
F
S
P
S
Q
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
99.8
97.7
N.A.
96.7
72.5
N.A.
85.5
83.1
20.2
77.5
N.A.
57.1
N.A.
52
60.7
Protein Similarity:
100
99.4
99.8
98.9
N.A.
98.5
81.8
N.A.
89.8
89.3
34.2
86.9
N.A.
73.3
N.A.
68.7
74.1
P-Site Identity:
100
100
100
93.3
N.A.
100
66.6
N.A.
93.3
13.3
6.6
46.6
N.A.
33.3
N.A.
20
33.3
P-Site Similarity:
100
100
100
100
N.A.
100
80
N.A.
100
40
20
80
N.A.
60
N.A.
53.3
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
65
0
8
8
0
43
15
0
0
0
0
% A
% Cys:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
58
0
0
0
8
0
0
0
0
8
% D
% Glu:
0
8
0
0
0
8
0
8
29
0
0
0
0
8
0
% E
% Phe:
0
43
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
15
0
0
0
8
15
72
0
0
0
% G
% His:
0
0
22
0
0
0
0
8
15
0
0
0
0
0
0
% H
% Ile:
8
0
0
8
0
0
8
8
0
0
0
0
8
8
8
% I
% Lys:
0
0
8
0
0
0
8
0
8
0
0
8
8
0
0
% K
% Leu:
79
0
0
72
8
0
79
0
0
0
0
8
0
50
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
8
0
0
8
8
0
15
43
0
0
0
0
0
15
% N
% Pro:
0
0
0
0
0
8
0
0
0
15
0
8
8
0
0
% P
% Gln:
0
0
58
0
0
0
0
0
0
15
0
0
0
8
0
% Q
% Arg:
0
0
8
0
0
0
0
0
0
0
8
8
72
0
0
% R
% Ser:
0
0
0
8
15
0
0
0
8
8
36
0
8
0
8
% S
% Thr:
0
0
8
0
0
0
0
0
0
0
22
0
0
8
58
% T
% Val:
0
0
0
15
0
0
0
8
0
0
8
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
43
0
0
0
0
0
50
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _