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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC22A3 All Species: 26.97
Human Site: S324 Identified Species: 53.94
UniProt: O75751 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75751 NP_068812.1 556 61280 S324 K Y L S S N Y S E I T V T D E
Chimpanzee Pan troglodytes XP_001152133 556 61220 S324 K Y L S S N Y S E I T V T D E
Rhesus Macaque Macaca mulatta XP_001097972 676 74091 S445 K Y L S S S Y S Q I T V T D E
Dog Lupus familis XP_533467 537 59128 S318 K Y L S P N Y S E I T V T D E
Cat Felis silvestris
Mouse Mus musculus Q9WTW5 551 61034 S319 K H L S S N Y S E I T V T D E
Rat Rattus norvegicus O88446 551 61031 S319 K H L S S N Y S E I T V T D E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515393 362 40716 I150 Q M F F T L G I I I L P G I A
Chicken Gallus gallus XP_419620 540 59928 S318 K Y L S P H Y S E I T V S N M
Frog Xenopus laevis Q66J54 558 62434 D317 T L E S M R S D M I K E L A C
Zebra Danio Brachydanio rerio NP_998315 562 62704 T321 T L S K K I E T L K D D N I D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VCA2 548 60985 K311 V D E V A E K K K Q D E M A A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9U539 585 65444 Q333 V D S M K N H Q N A A E E K E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 78.4 89.5 N.A. 86.3 86.1 N.A. 54.8 71 32.4 51.2 N.A. 34.3 N.A. 27.5 N.A.
Protein Similarity: 100 99.6 79.5 92.4 N.A. 91.5 92 N.A. 58.9 83 52.3 70.2 N.A. 55.2 N.A. 47.5 N.A.
P-Site Identity: 100 100 86.6 93.3 N.A. 93.3 93.3 N.A. 6.6 66.6 13.3 0 N.A. 0 N.A. 13.3 N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 100 100 N.A. 20 86.6 13.3 13.3 N.A. 13.3 N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 9 0 0 0 0 9 9 0 0 17 17 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % C
% Asp: 0 17 0 0 0 0 0 9 0 0 17 9 0 50 9 % D
% Glu: 0 0 17 0 0 9 9 0 50 0 0 25 9 0 59 % E
% Phe: 0 0 9 9 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 9 0 0 0 0 0 9 0 0 % G
% His: 0 17 0 0 0 9 9 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 9 0 9 9 75 0 0 0 17 0 % I
% Lys: 59 0 0 9 17 0 9 9 9 9 9 0 0 9 0 % K
% Leu: 0 17 59 0 0 9 0 0 9 0 9 0 9 0 0 % L
% Met: 0 9 0 9 9 0 0 0 9 0 0 0 9 0 9 % M
% Asn: 0 0 0 0 0 50 0 0 9 0 0 0 9 9 0 % N
% Pro: 0 0 0 0 17 0 0 0 0 0 0 9 0 0 0 % P
% Gln: 9 0 0 0 0 0 0 9 9 9 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 17 67 42 9 9 59 0 0 0 0 9 0 0 % S
% Thr: 17 0 0 0 9 0 0 9 0 0 59 0 50 0 0 % T
% Val: 17 0 0 9 0 0 0 0 0 0 0 59 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 42 0 0 0 0 59 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _